Physical Sciences & Engineering

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E. Hamden (Space Institute) 

 Limiting Language
Applicants and partners, subcontractors, or consortium members, include, but are not necessarily limited to, registered U.S. and non-U.S. non-profit organizations; for-profit organizations and small businesses; private voluntary organizations; foundations; private institutions of higher education, public or state institutions of higher education; and faith-based and community institutions. All applicants must be legally registered organizations prior to applying to this announcement. Applicants may submit only one application.

Synopsis
The United States has a unique opportunity to drive select countries in the Middle East and North Africa firmly into the U.S. space ecosystem. Countries within the Middle East and North Africa region are increasingly eager to develop their space capabilities to both diversify their economies and expand their nation’s expertise in science and technology. These countries are looking to cooperate with partners with advanced capabilities in space sciences, and this project aims to position the United States as the partner of choice by engaging and empowering a new generation of leaders in target countries with the necessary skills to harness the global space economy’s vast opportunities.

This initiative seeks an implementing partner with demonstrated expertise in building capacity for shaping and navigating space policy, diplomatic and leadership skills, technical know-how, and business engagement. This approach ensures participants acquire practical skills for space sector advancement while reinforcing United States Government values of responsible technological practices, transparency, innovation, and security. Emphasizing technological interoperability among space partners will drive substantial commercial opportunities for U.S. private sector companies while building sustainable international cooperation frameworks aligned with American space governance principles.

Internal Competition Under Review // Limit: 1 // Tickets Available: 1

Limiting Language
An institution may submit only a single proposal in response to this solicitation, as the lead institution.

If more than one proposal is submitted from an institution, the first proposal submitted from that institution will be considered, and remaining proposals will be returned without review.

An institution may serve as a non-lead institution on more than one proposal.

Synopsis of Program
Autonomous experimentation is poised to accelerate research and unlock critical scientific advances that bolster U.S. competitiveness and address pressing societal needs. Programmable Cloud Laboratories are able to execute automated workstreams, including self-driving lab workflows, to efficiently move research goals through artificial intelligence (AI) enabled experiment design, laboratory preparations, data collection, data analysis and interpretation. While limited-scale efforts have shown promise, versatile programmable and self-driving labs capable of addressing complex research questions with trustworthy results will require coordinated technological advances and an engaged research community. Additional challenges include the availability of automated laboratory infrastructure, standardized approaches to data collection for interoperability, advances in AI for data interpretation and experimental design, and more. This solicitation aims to address such gaps and realize the potential of autonomous experimentation.

The Test Bed: Toward a Network of Programmable Cloud Laboratories (PCL Test Bed) program seeks to establish and facilitate the operation of distributed autonomous laboratory facilities. These laboratories will combine technological and human capacity to enable integration, testing, evaluation, validation, and translation of cutting-edge technology solutions in automated science and engineering. The PCL Test Bed will consist of a set of Programmable Cloud Laboratory Nodes (PCL Nodes) that can be remotely accessed to run custom workflows specified and programmed by users, that are linked together via computational networking, shared science questions, and data and artificial intelligence (AI) standards.

The PCL Test Bed will facilitate access to advanced scientific equipment, accelerate translation and scaling of basic research into industry applications, enhance reproducibility and the exchange of experimental data, and assist in training the next generation of scientists and engineers in state-of-the art methodologies. It will help develop community norms, best practices, and formal standards for automated laboratory procedures, workflows, and instrument testing and validation. It will also advance consistent practices for the collection, sharing, and use of metadata and training data and the use and exploitation of AI methods. This program will also support the development of automated laboratory methods, including self-driving autonomous experiment workflows.

Proposals must have a set of well-defined science drivers poised to derive significant benefit from targeted use of the PCL Test Bed capabilities, including but not limited to synthesis, optimization, and/or characterization experiments, in specific sub-disciplines within materials science, biotechnology, chemistry or other areas of science and engineering. These science drivers will guide the protocols and standards necessary for each node and facilitate collaboration across the Test Bed. For example, science drivers could include but are not limited to:

• Materials science, materials synthesis and characterization efforts that advance U.S. competitiveness.
• Biotechnology experiments in scalable, high-throughput engineering and characterization services for proteins or microbes with novel applications in the U.S. bioeconomy.
• High-throughput experimentation for the accelerated development of catalysts to support more efficient chemical synthesis to address urgent national needs.

User Recruitment and On-Boarding Workshops will be a key component of the PCL Test Bed program and will serve to recruit users to individual PCL Nodes and the Test Bed to help make progress on the proposed science drivers, provide access to technology, test the limits of the experimental set-up of the nodes, and explore new research opportunities between the PCL Nodes and institutions including, but not limited to, R2 Universities, PUI (Primarily Undergraduate Institutions), and two-year institutions.

The PCL Test Bed will be available to researchers in academia as well as industry, including current and former awardees from the Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) programs. The portfolio of projects is available here, https://seedfund.nsf.gov/portfolio.

PCL Nodes are expected to develop and implement plans for continued operation after the period of this award.

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L. O'Neill - (Center on Aging)

Limiting Language
My organization is a government, a tribal entity, or a university: You may submit one application per department. You may submit another if, and only if, you are collaborating with another organization.  
o If you would like to submit a second application on behalf of a collaborative group of organizations, submit only one application per project. This means choosing just one organization to submit the collaborative application.  
o If several departments are applying for the same project, please treat it as a collaborative application. 
o A government or tribal agency, or university may apply for projects separate from those the individual departments apply for.   

Grant Description
All organizations requesting grants must provide services that directly benefit populations residing in Cochise County and eastern Santa Cruz Counties. 

The Legacy Foundation of Southeast Arizona is seeking applications for Innovative grants.  

Grant Cycle – June 2, 2025 through September 26, 2025. Awards will be announced by December 13, 2025.  Grants will be awarded January 2026.  

Every year the Legacy Foundation of Southeast Arizona funds Innovation Grants for projects up to $50,000 that are aligned with the Foundation Mission of Promoting Population Health and Community Wellness. 

Collaboration and forging partnerships with other community organizations are key determinants in funding decisions. 

The Legacy Foundation of Southeast Arizona will kick off the Innovative Grant Cycle with a workshop that will provide full information regarding the goals of the cycle. 
 

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O. Zhupanska (Aerospace and Mechanical Engineering)
M. Krunz (Electrical and Computer Engineering)
B. Revil-Baudard (Materials and Science Engineering)

Limiting Language:

Each PPP is limited to a maximum of four PIs. No university shall exceed leading three PPPs. Candidate must be a University Consortium Member prior to submitting a Notice of Intent (NOI)

Topics: 

1. TOPIC 1: IMPROVED SUB-SCALE HYPERSONIC AIR-BREATHING PROPULSION TEST CAPABILITIES  
2. TOPIC 2: DIGITAL TWIN ARCHITECTURE FOR HYPERSONIC AIR-BREATHING SYSTEM AND MISSION DESIGN TRADE STUDIES
3. TOPIC 3: SHOCK PROPERTIES OF ADDITIVELY MANUFACTURED MATERIALS (AMM)
4. TOPIC 4: EXPERIMENTAL & MODEL BASED ENDOTHERMIC FUEL PROPERTIES
5. TOPIC 5: CERAMIC TESTING FOR HYPERSONIC VEHICLES
6. TOPIC 6: MITIGATION OF THERMAL DEGRADATION IN HYPERSONIC WINDOWS
7. TOPIC 7: NETWORKING AND COLLABORATIVE COMMUNICATIONS 

Questions regarding the Project Call may be emailed to UCAH@tamu.edu through September 5, 2025 at 5:00 PM EST. Answers to the questions will be posted on the UCAH website for this RPP Project Call. All questions and answers will be made available to all proposers, unless they involve proprietary or CUI material. 

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Concept paper - Limit: 1 // Tickets Available: 1

Associated Application - Limit: 1 // Tickets Available: 0 
H. Jin (Systems and Industrial Engineering)

Limiting Language
An entity may submit only one concept paper and one associated application to this NOFO. The concept paper and application must address no more than one topic area identified in Key Facts section above. If an entity submits more than one concept paper the DOE will only review the last submission. Thislimitation does not prohibit an applicant from collaborating on other applications (e.g., as a potential subrecipient or partner) so long as the entity is listed as the applicant on only one concept paper and one associated application submitted under this NOFO.

Executive Summary
The Advanced Materials and Manufacturing Technologies Office (AMMTO) supports the development of a globally competitive U.S. energy industrial base that drives supply chain resiliency and energy security through materials and manufacturing innovation. The development of circular supply chains that enable efficient use of materials through reuse, repair, remanufacture, and recycling is important toward accomplishing these goals.1,2 Efforts to achieve a robust and competitive manufacturing sector through innovation in circular supply chains cannot be successful without: (1) a comprehensive understanding of the landscape of technical and non-technical factors that could impact the adoption of emerging technologies and (2) strong connections across the circularity field to accelerate innovations from R&D- scale to commercial practice. This NOFO seeks to establish a new accelerator which will address this need through the development of a comprehensive technical and market analysis portfolio and stakeholder engagement activities.

The Accelerator’s analysis portfolio will establish a comprehensive understanding of both technical and non-technical factors impacting the adoption of emerging technologies for circular supply chains. Technical factors of interest include the state of emerging technologies in terms of performance and cost metrics. Awareness of these technical factors requires strong understanding of the R&D landscape as well as the state of industrial practice. Non-technical factors of interest include market conditions, supply chain dynamics, policy and regulatory landscape, workforce readiness, infrastructure capabilities, among others. These non- technical market factors may be region-specific and would be critical to inform a systems-level perspective of potential barriers and pathways to widespread commercial adoption. The Accelerator will leverage understanding of technical and non-technical factors to analyze market opportunity within specific product and material market segments. This will identify specific early adopter markets and seq

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B. Bash (Elecrical and Computer Engineering)
I. Barton (Mining Engineering & Mineral Resources)

Limiting Language:
We welcome you to submit up to two nominations from University of Arizona. 

Eligibility Criteria:

• Have achieved tenure or an equivalent status prior to the nomination deadline and within the past three calendar years (between January 1, 2022 and August 10, 2025),
• Have a remarkable record of accomplishment in mathematics, computer science, natural sciences, and/or engineering,
• Have a demonstrated history of pursuing and publishing results in more than one field,
• Have a desire and plan to expand their research portfolios by exploring a substantive disciplinary or methodological shift, but have not yet launched such shifts,
• Demonstrate a need for additional funding to enable new experiments, explorations, or shifts in research directions.

Overview
We are especially interested in supporting highly creative, original, and risky research that is clearly distinct from past areas and directions. We strongly encourage you to consider nominating not simply your most accomplished researchers, but specifically extraordinary researchers whose work and ideas are adventurous, bold, highly creative, and less likely to receive traditional funding or support. Successful applicants propose potential new projects that are wholly original and very different from any of their past work.
 

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M. Bhattacharya (Neuroscience)
J. Streicher (Pharmacology)
K. Huntoon (Neurosurgery)

The mission of The G. Harold and Leila Y. Mathers Foundation is to advance knowledge in the life sciences by sponsoring scientific research that will benefit mankind. The foundation’s grants program seeks to support basic science, ideally with potential translational applications. Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.

For many years the Foundation has enjoyed special recognition in the research community for supporting “basic” scientific research, realizing that true transformative breakthroughs usually occur after a thorough understanding of the fundamental mechanisms underlying natural phenomena. More recently, and with the advent of newer investigative methodologies, technology, and tools, the Foundation now embraces innovative translational research proposals.

The grant duration must be three years. The budget should be reasonable based on the aims of the project. Indirect costs may not exceed 10%. Preliminary Budgets are required during the LOI phase. A detailed budget justification is not required until the proposal phase. The Foundation’s grant award is not intended to be utilized for purchasing capital equipment (“bricks-and-mortar”) for the lab and is intended only to support the actual investigation. The Foundation assumes and expects that capital equipment must be provided by the research institution or university.

Application Guidance:

• Grant budgets cannot exceed $600-750K
• The Foundation primarily supports basic science, ideally with potential translational applications.
• Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.
• Covid-19-related research projects (aims or sub-aims) will not be considered for support.
• Medical imaging technology-related projects and/or electrical engineering technology development projects will not be considered for support.
• Plant Biology Research, Oceanography, Space Exploration. and Global warming-related research will not be considered for support.
• As technology continues to advance, it is apparent that investigations in the area of basic science and translational research may become more and more reliant on collaborative, interdisciplinary projects. It is important to note that any interdisciplinary project proposals may require additional information regarding the collaborator(s)’ achievements and relevant expertise.
• Feedback for declined LOI Requests will not be provided; LOIs or Formal Proposals that have been declined should not be resubmitted at a later date for consideration.
• Renewal applications for the same or related research will not be accorded priority consideration. It is strongly advised that any re-application for grant renewal consider a new direction based on prior research or emphasize some new potential translational aspects and not merely an extension of previously funded research.
• Requests for funding previously federally supported research and/or applications pending federal approval will not be accorded priority consideration.
• Requests for support of clinical trials or drug discovery will not be approved. The Foundation will not support projects which we consider pre-clinical drug development.

Fall 2025

Nominations and Portal Registration due date: September 19, 2025 (Friday, 8 PM EST (5 PM PST)
Nominations can be submitted beginning August 1, 2025.

Due date for LOI applications: October 3, 2025 (Friday, 8 PM EST (5 PM PST) 
Applicants notified of proposal invitation or LOI rejection within one month of the due date. 

Due date for invited formal proposals: December 12, 2025 (Friday, 8 PM EST (5 PM PST) 
Applicants are notified of proposal approval or rejection within 2 ½ months of the due date. 

 *Late nominations and/or registrations will not be approved.
 

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M.M. Kaelberer (Physiology)

Program Overview
The Searle Scholars Program supports research of outstanding individuals who have recently begun their appointment at the assistant professor level, and whose appointment is their first tenure-track position at a participating academic or research institution. Today, 168 institutions are invited to participate in the Program.

The Program was established at The Chicago Community Trust in 1980 and has been administered by Kinship Foundation since 1996. The Program is funded from the estates of Mr. and Mrs. John G. Searle. Mr. Searle was the grandson of the founder of the world-wide pharmaceutical company, G.D. Searle & Company. It was Mr. Searle's wish that certain funds be used to support "...research in medicine, chemistry, and the biological sciences."

Each year 15 new individuals are named Searle Scholars. Awards are currently set at $100,000 per year for three years. Since its inception, 617 Scholars have been named and over $174 million has been awarded.

Eligibility
The Searle Scholars Scientific Advisory Board is primarily interested in the potential of applicants to make innovative and high-impact contributions to research over an extended period of time.

Applicants for the 2026 competition (awards which will be activated on July 1, 2026) are expected to be pursuing independent research careers in biochemistry, cell biology, genetics, immunology, neuroscience, pharmacology, and related areas in chemistry, medicine, and the biological sciences.

Applicants should have begun their appointment as an independent investigator at the assistant professor level on or after May 1, 2024. The appointment must be their first tenure-track position (or its nearest equivalent).

Institutions which do not have tenure-track appointments should consult with the Scientific Director of the Program regarding eligibility of selected applicants PRIOR to nominating such individuals.

The Searle Scholars Program does not ordinarily support purely clinical research but has supported research programs that include both clinical and basic components. Potential applicants who are unsure if their research is appropriate for our Program are encouraged to examine the research interests of present and former Searle Scholars on this website.

Applicants who were nominated for awards in the previous competition year but were not awarded may still meet the eligibility criteria for the current competition. Institutions should consult with the Scientific Director of the Program regarding renomination of such individuals.

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L. Folks (Electrical and Computer Engineering)

The submission for this funding program is coordinated by the Center for Semiconductor Manufacturing. Please contact Dan Moseke, Projects Director, for more information.

Limiting Language
NATCAST will only accept one proposal per lead applicant. 

For the purposes of this CFP, Natcast defines a single applicant by its Unique Entity Identifier (UEI) number. Although it is technically possible for multiple entities with separate UEI numbers from the same system to submit individual proposals, such a practice is discouraged.