Physical Sciences & Engineering

No Applicants // Limit: 1 (Topic Area 2) // Tickets Available: 1

Limiting Language
An entity may submit only one concept paper and one associated application for each topic area of this NOFO. If an entity submits more than one, we will only review the last timely submission. Any other submissions listing the same entity as the applicant for the same topic area will not be eligible. This limitation does not prohibit an entity from collaborating on other applications (e.g., as a potential subrecipient or partner) so long as the entity is only listed as the applicant on one concept paper and one associated application for each topic area of this NOFO.

Topic Area 2 Overview
The Smart Grid Topic Area aims to support projects focused on deploying advanced grid technologies. This initiative is looking for innovative application of cutting-edge, marketready technologies, which may include new devices, materials, engineering designs, or software tools. These projects are intended to strengthen grid reliability and resilience through reconductoring and deploying other Advanced Transmission Technologies. Projects will expand the transfer capability of existing transmission and sub-transmission lines, improve system flexibility, and reduce the likelihood and consequences of disruptive events. This topic supports projects that enhance the efficiency, reliability, and operational flexibility of the electric grid through smart grid technologies that enable real-time monitoring, control, and optimization of grid assets. DOE will focus primarily on projects that combine Advanced Transmission Technologies and reconductoring to achieve measurable increases in transfer capability and operational intelligence. 

Projects must demonstrate how digitalization, automation, and data-driven technologies improve existing transmission and sub-transmission systems while delivering measurable affordability benefits to ratepayers through reduced congestion costs, deferred capital investment, and improved efficiency of existing assets. Projects should provide quantifiable improvements in grid performance, situational awareness, and resilience through modernization and smart control. DOE seeks applications for smart grids, specifically those designed to support new load integration, that: 

• Integrate ATTs or reconductoring in ways that enable dynamic operations and increase transfer capability on existing rights-of-way
• Deploy advanced conductors and smart grid technologies that improve operational flexibility, reliability, and affordability
• Enhance data visibility and control through communications, automation, and analytics that directly support improved reliability
• Provide replicable approaches for regional scale-up and commercialization of combined ATTs and reconductoring deployments
• Support integration of backup generation enabling solutions (e.g., controls, telemetry, coordination) tailored for large load integration with mechanisms for grid-support services

Internal Competition Undergoing Peer Review // Limit: 8 Concept Papers, 2 Phase I Proposals (1 Medical Research, 1 Science and Engineering)

 Program Description

Full sponsor guidelines: https://www.wmkeck.org/research-overview/

The mandate of the W.M. Keck Research Program is to support pioneering discoveries in Science, Engineering, and Medical Research.  The Foundation funds the high-risk and high-impact work of leading researchers to lay the groundwork for new paradigms, technologies, and discoveries that will save lives, provide innovative solutions and add to our understanding of the world.

Keck funded projects are distinctive and novel in their approach, question the prevailing paradigm, or have the potential to break open new territory in their field.  We prioritize grants that pioneer biological and physical science research and engineering, including the development of promising new technologies, instrumentation or methodologies.

Fit Self-Test: A Keck-ready idea can answer “yes” to most of the following questions:

• Does it discover how something works?
• Does it challenge an existing assumption?
• Is failure still scientifically valuable?
• Would federal agencies likely say, “too early”?

Keck Prioritizes:

• Work that is paradigm shifting, or challenges a prevailing hypothesis
• Work that creates a new field, or bridges disparate fields
• Work that departs from current approaches or challenges existing assumptions or frameworks
• Fundamental basic science questions focused on how systems work and the underlying mechanisms that govern them
• Discovery-driven logic
• Research where failure is informative

Keck Disfavors:

• Clinical or translational research (i.e., development of therapeutics)
• Outcome or patient impact framing
• Biomarkers as endpoints
• Engineering for its own sake
• Large mammal studies when they function as clinical or validation trials
• Already funded or derivative work

Important notes:

• Keck seeks to fund basic science that advances fundamental understanding
• Keck funds science, not engineering – unless engineering is essential to answer a scientific question
• Keck funds medical research, not clinical research
• Federal rejection is not required, but Keck fills gaps where federal agencies are too risk adverse.
• Keck does not consider tools, platforms, or methods as the primary idea. Tools, AI, and engineering may be supported only if required to answer a basic scientific question. 

The submission for this funding program is coordinated by the Center for Semiconductor Manufacturing. Please contact Dan Moseke, Projects Director, for more information.

K. Muralidharan (Center for Semiconductor Manufacturing)

Limiting Language
Institutes should limit their submissions to no more than 2 proposals for each degree cohort.

Overview
Intel Corporation, in collaboration with Semiconductor Research Corporation (SRC), invites universities located in Ohio, Oregon, Arizona, and New Mexico to submit proposals for participation in the Intel Scholarship & Fellowship Program. This program is designed to build a pipeline of highly skilled professionals with advanced degrees in semiconductor-related disciplines in regions where Intel has significant operations. The initiative will provide funding to support scholarships and fellowships for eligible MS and PhD students. A key desired outcome is to increase retention and degree attainment in advanced degrees in engineering and STEM disciplines of interest to the semiconductor industry.   Selected institutions will collaborate with SRC and Intel personnel to recruit, mentor, and support students in critical academic disciplines, preparing them for careers in semiconductor innovation 

No Applicants // Limit: 1 // Tickets Available: 1

Limiting Language
Yes, each lead organization can submit only one application.

Program Description
ENERGYWERX, through a Partnership Intermediary Agreement (PIA) with the U.S. Department of Energy (DOE) Interconnection Innovation e-Xchange (i2X) program, is looking to fund pilot tests of innovative interconnection solutions under the Interconnection Cost Reduction Solutions for Distribution (iCRS-D) program. This program will help address the National Energy Emergency by supporting innovations to streamline and expedite interconnection services by implementing cutting-edge technology solutions, such as grid enhancing technologies, grid-interactive loads, flexible interconnection, micro-grids, and many other innovations. The iCRS-D program aims to reduce interconnection costs related to grid upgrades by 70% for generators, large loads, and hybrid facilities connecting to the distribution grids.

To usher in a new era of American prosperity, we must ensure all Americans and domestic industries have access to affordable, reliable, and secure electricity. United States electricity demand is growing at an extraordinary pace due to the rapid rise of large commercial and industrial loads (e.g., data centers) and electrification. The challenge is compounded as Americans face rising electricity prices across the country.

The iCRS-D Program will provide $4 million to fund up to four organizations, each of which will lead a multi-stakeholder partnership at the local, state, or regional level. Each partnership will execute a Lighthouse Project - a pilot program that develops and demonstrates new technologies and effective solutions - to increase data access and transparency, streamline and expedite interconnection services, and maximize economic efficiency. Lead organizations, with their partners, will apply their distribution-level interconnection expertise to prioritize and adapt practical solutions for load and generation interconnection. These efforts will deliver tested approaches to scalable interconnection innovations that improve processes, reduce overall costs, and maintain a reliable grid.

Institutionally Coordinated // Limit: 3 // Tickets Available: 0

J. Schaibley (Physics)
D. Soh (Optical Sciences)
S. Ndlovu (Mining Engineering and Mineral Resources)

Limiting Language
Applicant institutions are limited to no more than three pre-applications or applications as the lead institution.

An individual may not be named as the PI (EFRC Director) on more than one pre-application or application. Directors of existing EFRC awards that do not have project end dates in 2026 cannot be named as the EFRC Director on any pre-application or application in response to this NOFO.

There is no limitation to the number of applications on which an institution appears as a subrecipient. 

Should DOE receive submissions in excess of the applicable limits, DOE reserves the right, in its sole discretion, to request additional or clarifying information to ascertain the institution’s intended submissions. Otherwise, DOE will consider the latest received submissions to be the institution’s intended submissions.
• Pre-applications in excess of the limited number of submissions may be discouraged.
• Applications in excess of the limited number of submissions may be declined without review.

Program Description
The DOE SC program in Basic Energy Sciences (BES) announces a re-competition of the Energy Frontier Research Center (EFRC) program. The purpose of this program is to bring together world-class teams of scientists from universities, DOE national laboratories, and other institutions to perform energy-relevant basic research with a scope and complexity beyond what is possible in single-investigator or small-group awards. These multi-investigator, multi-disciplinary centers accelerate transformative scientific advances for the most challenging topics in materials sciences, chemical sciences, geosciences, and biosciences. EFRCs integrate experiments, theory, computation, and AI/ML; develop innovative experimental and theoretical tools that illuminate fundamental processes in unprecedented detail; and create an enthusiastic, interdisciplinary, workforce of energy-focused scientists.

Limit: 1 // Tickets Available: 0

K. Muralidharan (Materials Science and Engineering) 

Limiting Language
Limit on Number of Proposals per Organization: 1

Program Description 
NSF NQNI responds to national and community research priorities that will advance nanoscale and quantum science and engineering and grow U.S. leadership in critical and emerging technologies. These include quantum technology, semiconductors, artificial intelligence (AI), manufacturing, biotechnology, and others.

NQNI will provide broad access to domestic QISE research infrastructure as called for in the National Quantum Initiative (NQI) Act of 2018 (Public Law 115-368) and Administration priorities. NSF support for world-class research infrastructure will help U.S. researchers meet the needs of innovative quantum systems.

NSF developed the NQNI program with input on future research infrastructure needs from academia, government, industry, and U.S. National Laboratories. The workshop report, Nanotechnology Infrastructure of the Future (2023, NSF award 2331369), emphasized the need to continue supporting nanotechnology infrastructure; it concluded that such resources are "essential for quantum science and engineering and other emerging national research priorities." The workshop report, Workshop on Quantum Engineering Infrastructure II (2025, NSF award 2405015), affirmed that NSF nanofabrication infrastructure programs are highly valuable for quantum research; it also stated that such infrastructure should support quantum "technologies that require higher-levels of integration, yet have the flexibility to work with emerging platforms."

No Applicants // Limit: 1 // Tickets Available: 1 

Limiting Language
The University of Arizona is only eligible to submit to Topic Area 2: General Scientific Infrastructure (GSI)

Topic Area 2: General Scientific Infrastructure (GSI)
An eligible applicant may submit only one application to this topic area. If an entity submits more than
one full application, the DOE will only review the last submission.

Program Purpose 
The Office of Nuclear Energy’s (NE) program purpose is to advance nuclear energy science and technology to meet U.S. energy, environmental and economic needs. NE enables innovation, supports unique research infrastructure, and solves crosscutting challenges facing the nuclear energy sector through research, development and demonstration. NE has identified the following goals to address challenges in the nuclear energy sector, help realize the potential of advanced technology, and leverage the unique role of the government in spurring innovation:

• Enable continued operation of existing U.S. nuclear reactors.
• Enable deployment of advanced nuclear reactors.
• Develop advanced nuclear fuel cycles.
• Maintain U.S. leadership in nuclear energy technology.

Investing in the next generation of nuclear energy leaders and advancing university-led nuclear
innovation is vital to fulfilling NE's mission, which is primarily accomplished through NE’s Nuclear Energy
University Program (NEUP). NEUP was established in 2009 to consolidate NE’s university support and
enable the integration of university research within NE’s technical programs. Through various
competitive award opportunities, the program engages with U.S. universities and colleges to conduct
research and development (R&D), enhance infrastructure, and support student education, thereby
contributing to the development of a world-class nuclear energy and workforce capability.

Expected Performance Goals:
Topic Area 2: General Scientific Infrastructure (GSI)

• Procurement of equipment, software, instrumentation, and associated non-reactor upgrade
  requests that support nuclear energy-related R&D or education.
• Procurement of equipment and instrumentation for specialized facilities, classrooms, and
  teaching laboratories, and non-reactor NS&E research.
• Procurement of infrastructure that supports the sharing and use of equipment and
  instrumentation by multiple campuses of a university, multiple universities, or with national
  laboratories is encouraged.

Limit: 2 // Tickets Available: 0

Kenry (Pharmacology and Toxicology)
B. Miles (Astronomy)

Please note that this internal competition is being run on an anticipated funder deadline based on prior cycles. It is subject to update when we receive additional information from the Packard Foundation. 

Limiting Language
Invited institutions may submit two nominations

Overview
In 1988, the Foundation established the Packard Fellowships for Science and Engineering to allow the nation's most promising early career professors to pursue their science and engineering research with few funding restrictions and limited paperwork requirements. Disciplines that will be considered include physics, chemistry, mathematics, biology, astronomy, computer science, earth science, ocean science, and all branches of engineering. Candidates engaged in research in the social sciences will not be considered.

Eligibility 
Candidates must be faculty members at one of the 50 Invited Institutions. Candidates must be eligible to serve as principal investigators engaged in research in the natural and physical sciences or engineering and must be within the first three years of their faculty careers. Disciplines that will be considered include physics, chemistry, mathematics, biology, astronomy, computer science, earth science, ocean science, and all branches of engineering. Candidates engaged in research in the social sciences will not be considered.

Full guidelines are linked here. 

Limit: 3 // Tickets Available: 0

M. Bhattacharya (Neuroscience)
P. Arunachalam (Immunobiology)
N. Lee (Pharmacology)

The mission of The G. Harold and Leila Y. Mathers Foundation is to advance knowledge in the life sciences by sponsoring scientific research that will benefit mankind. The foundation’s grants program seeks to support basic science, ideally with potential translational applications. Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.

For many years the Foundation has enjoyed special recognition in the research community for supporting “basic” scientific research, realizing that true transformative breakthroughs usually occur after a thorough understanding of the fundamental mechanisms underlying natural phenomena. More recently, and with the advent of newer investigative methodologies, technology, and tools, the Foundation now embraces innovative translational research proposals.

The grant duration must be three years. The budget should be reasonable based on the aims of the project. Indirect costs may not exceed 10%. Preliminary Budgets are required during the LOI phase. A detailed budget justification is not required until the proposal phase. The Foundation’s grant award is not intended to be utilized for purchasing capital equipment (“bricks-and-mortar”) for the lab and is intended only to support the actual investigation. The Foundation assumes and expects that capital equipment must be provided by the research institution or university.

Application Guidance:

• Grant budgets cannot exceed $600-750K
• The Foundation primarily supports basic science, ideally with potential translational applications.
• Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.
• Covid-19-related research projects (aims or sub-aims) will not be considered for support.
• Medical imaging technology-related projects and/or electrical engineering technology development projects will not be considered for support.
• Plant Biology Research, Oceanography, Space Exploration. and Global warming-related research will not be considered for support.
• As technology continues to advance, it is apparent that investigations in the area of basic science and translational research may become more and more reliant on collaborative, interdisciplinary projects. It is important to note that any interdisciplinary project proposals may require additional information regarding the collaborator(s)’ achievements and relevant expertise.
• Feedback for declined LOI Requests will not be provided; LOIs or Formal Proposals that have been declined should not be resubmitted at a later date for consideration.
• Renewal applications for the same or related research will not be accorded priority consideration. It is strongly advised that any re-application for grant renewal consider a new direction based on prior research or emphasize some new potential translational aspects and not merely an extension of previously funded research.
• Requests for funding previously federally supported research and/or applications pending federal approval will not be accorded priority consideration.
• Requests for support of clinical trials or drug discovery will not be approved. The Foundation will not support projects which we consider pre-clinical drug development.
  
   

Please note, while RDS will manage submitting the institutional nomination, it is the responsibility of the selected faculty members to complete the portal registration by the January 30, 2026 at 8pm EST deadline.

Institutionally Coordinated // Limit: 3 // Tickets Available: 1

Track 3: Limit: 1 // Tickets Available: 1

Track 4: Limit: 1 // Tickets Available: 0
D. Hockstad (Tech Launch Arizona)

Track 5: No Applicants // Limit: 1 // Tickets Available: 1

This funding opportunity requires institutional coordination with Tech Launch Arizona. If you are interested in submitting a proposal, please contact Doug Hockstad.  

Limiting Language
The University of Arizona is eligible for tracks 3, 4, and 5 (high research translation readiness level category). For Tracks 3, 4, and 5, an eligible organization can submit a maximum of one proposal per Track. 

Track Synopses 
  
Track 3: Technology Transfer Resource Centers (RESOURCE)   

• The ART program aims to leverage the experience and resources of IHEs or non-profits with strong research translation capacity (and/or experience) to launch a network of regional Technology Transfer Resource Centers (RESOURCE) that promote regional technology transfer and technology development activities available to multiple IHEs in a region with low or emerging research capacity and little or no dedicated technology transfer or research translation resources.  A Track 3 award for a RESOURCE is expected to provide guidance, training, education, and services to other IHEs in a region who have a low RTRL. A Track 3 award is expected to be up to a total of $8 million for a duration of 4 years. Subject to availability of funds and quality of proposals, NSF plans to make up to 5 RESOURCE awards. Some awardees demonstrating strong performance, as demonstrated by successfully meeting evaluation criteria during the award, including progress toward self-sustainability, may have an opportunity to receive renewal support for up to 4 more years and additional funding of up to $2 million, subject to the availability of funds. As noted above, the lead IHE for this Track is expected to be an IHE with a very high RTRL or a non-profit with significant expertise related to technology transfer, entrepreneurship and related areas leading to sustained economic impacts.      

  Track 4: Education and Training (ET)    

• This nationally focused Track invites proposals from IHEs or non-profits with any combination of either a strong, vibrant and established research translation ecosystem, and/or demonstrated experience to develop, evaluate, and deploy educational and training resources related to entrepreneurship, technology transfer and related activities. The beneficiaries for these education and training resources to be developed will be lower RTRL IHEs located anywhere in the United States (including but not limited to Track 1 and Track 2 awardees). Track 4 awards may be budgeted up to a total of $3 million for a duration of 3 years. Subject to availability of funds and quality of proposals, NSF plans to make up to 4 ET awards. Some awardees demonstrating strong performance, as demonstrated by successfully meeting evaluation criteria during the award, including progress toward self-sustainability, may have an opportunity to receive renewal support for up to 2 more years and additional funding up to $2 million (subject to the availability of funds), to scale up the deployment and adoption of the developed resources and training materials nationally.

Track 5: Coordinating Accelerating Research Translation (CART) 

• This Track invites proposals from IHEs or non-profits for the creation of a unifying center that will facilitate the development of an integrated platform for coordinating, evaluating, and monitoring the progress being made by teams that are supported under both Tracks 1 and 2. The CART awardee would also coordinate activities to be carried out under awards pursuant to Tracks 3 and 4. The Track 5 CART cooperative agreement award may be budgeted up to a total of $3 million for a duration of 5 years. Subject to availability of funds and quality of proposals, NSF plans to make up to 2 awards under the CART Track. Some awardees demonstrating strong performance, as demonstrated by successfully meeting evaluation criteria during the award, including progress toward self-sustainability, may have an opportunity to receive renewal for up to 5 more years and additional funding up to $3 million, subject to the availability of funds. Proposals for this Track must be led by one IHE with a high RTRL with significant expertise and experience in areas related to technology transfer, intellectual property management, entrepreneurship as well as initiatives and programs directed at sustained economic and collective impacts.