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Biomedical, Clinical & Life Sciences

The Experimental Therapeutics Clinical Trials Network (ETCTN) Lead Academic Organizations (UM1 Clinical Trial Required)

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Limiting Language
Only one application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed.

Purpose
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to maintain or establish Lead Academic Organizations (LAOs) as part of the NCI Experimental Therapeutics Clinical Trials Network (ETCTN). ETCTN LAOs will design, develop, monitor, conduct, and analyze early phase clinical trials (e.g., phase 0, phase 1, phase 2, pilot, and other experimental therapeutic clinical trials) involving agents under regulatory sponsorship for New Investigational Drug (IND) applications held by NCI's Division of Cancer Treatment and Diagnosis (DCTD), Cancer Therapy Evaluation Program (CTEP). Each ETCTN LAO will participate in clinical trials it leads as well as clinical trials led by other LAOs in the network. 

The ETCTN LAOs will provide oversight for all scientific, programmatic, financial, and administrative matters related to the sites participating in ETCTN trials as part of their LAOs. ETCTN LAOs are also expected to provide mentorship for investigators who are in the early stages of their research careers with a focus on clinical trials. All ETCTN LAOs will be required to use the ETCTN Pharmacokinetic (PK) Resource Laboratory as a central resource to incorporate PK studies within their early phase clinical trials, when appropriate, to analyze pharmacokinetic endpoints, drug-drug interactions, cytochromes P450 (CYP) interactions, pharmacodynamics, and food effects associated with IND agents being evaluated in ETCTN trials. This PK Laboratory will conduct all pharmacokinetic studies for ETCTN clinical trials involving Investigational New Drug (IND) agents under the regulatory sponsorship of NCI’s Division of Cancer Treatment and Diagnosis (DCTD), Cancer Therapy Evaluation Program (CTEP).  The ETCTN Pharmacokinetic Resource Laboratory  is funded through a separate award under the NOFO listed below.

  • The ETCTN – Network Pharmacokinetic Resource Laboratory under RFA-CA-27-017.
Funding Type
External Deadline
6/30/2026
Solicitation Type

Increasing awareness and knowledge of Alpha-gal Syndrome in the United States

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Summary 

This NOFO’s aim is to improve awareness and knowledge of alpha-gal syndrome (AGS) in the United States. AGS is an emerging condition and is not nationally notifiable. This will happen through:

  • The creation of a professional network of AGS researchers and public health professionals.
  • Improved surveillance.
  • Improved communications materials.

This NOFO seeks to improve:

  • AGS surveillance.
  • Patient care.
  • Awareness and understanding.
     

The NOFO’s three main strategies are to:

  • Share: Disseminate the latest knowledge about AGS among stakeholders to improve patient care for AGS and the public health response.
    • This includes public health agencies, academic researchers, and
      advocacy groups.
  • Track: Conduct active or enhanced surveillance for AGS.
    • This strategy could involve patient populations or geographic locations with limited access to specialized healthcare provider care.
  • Educate: Create AGS communications targeted at the general public, AGS patients, and/or people at higher risk for tick encounters (outdoor enthusiasts, dog owners, etc.).
    • Communications targeted at healthcare providers, healthcare provider educational resources, and training would also fall under this strategy.
Funding Type
External Deadline
6/19/2026

Arizona Trauma-Informed Substance Use Prevention Program (TISUPP)

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A. Dixon-Kleiber (Gila County Cooperative Extension)


Limiting Language
This solicitation only allows one application per eligible entity (amendment to RFGA forthcoming). 

Summary
Governor Katie Hobbs’ Office of Youth, Faith and Family, issues this Request for Grant Application (RFGA) Solicitation concerning the Arizona Trauma-Informed Substance Use Prevention Program (TISUPP) in accordance with A.R.S. §41-2701. Applications for this program will only be accepted through the State’s web-based grants management system, Euna Grants (formerly eCivis). The deadline for submission of an application in Euna will be on or before 11:59 PM (Arizona time) on June 15, 2026. It is anticipated that the results of this solicitation will be announced on September 15, 2026.

NIFA Equipment Grants Program

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A. Mukherjee (Cooperative Extension) 

Limiting Language
For FY 2026, an eligible institution may only submit two applications to this program as a lead institution and only one award will be made per lead institution. Prospective applicants/project directors are advised to contact their institutional office of research regarding processes used to select proposals for submission. To receive an award in FY 2026, the lead institution may not have received more than two (2) USDA-NIFA EGP awards as lead institution in the previous two (2) EGP funding cycles.

Executive Summary 
The Equipment Grants Program (EGP) serves to increase access to shared-use special purpose equipment/instruments for fundamental and applied research for use in the food and agricultural sciences programs at institutions of higher education, including State Cooperative Extension Systems. The program seeks to strengthen the quality and expand the scope of fundamental and applied research at eligible institutions by providing them with opportunities to acquire one shared-use piece of equipment/instrument that supports their research, research training, and extension goals that may be too costly and/or not appropriate for support through other NIFA grant programs. The program emphasizes shared-use instrumentation that will enhance the capabilities of researchers, educators, and extension specialists both within and outside the proposing organization. 

Funding Type
External Deadline
6/25/2026

Modern Equipment for Shared-use Biomedical Research Facilities: Advancing Research-Related Operations (S15 Clinical Trial Not Allowed)

The University of Arizona is not eligible for this funding opportunity

NIGMS will co-fund applications from higher education institutions that award undergraduate (B.S. or B.A.) and/or graduate degrees in biomedical sciences and have received no more than $6 million dollars per year (total costs) from NIH Research Project Grants (RPGs) in each of the preceding two fiscal years, calculated using NIH RePORTER, at the time of the application.  Applications to be considered must support research aligned with the NIGMS mission. Applications for research capacity building in Institutional Development Award (IDeA)-eligible states will be considered.  


 

Coccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)

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J. Galgiani (Valley Fever Center for Excellence)

Limiting Language
Only one application per institution (normally identified by having a unique entity identifier (UEI) number or NIH IPF number) is allowed.

Funding Opportunity Purpose
The purpose of the notice of funding opportunity (NOFO) is to solicit applications for a Coccidioidomycosis Collaborative Research Centers (CCRC) program. This new initiative will establish highly collaborative, multi-disciplinary, research teams to conduct translational and clinical research to support the development of a Valley fever vaccine as outlined in NIAID’s Strategic Plan for Research to Develop a Valley fever Vaccine.

 


 


 

FY 2025 Fire Prevention and Safety (FP&S) Grants Program

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J. Burgess (Community, Environment and Policy)

Limiting Language
Eligible applicants may submit only one application for each eligible activity under the FP&S Grant Program (one application under the FP&S Activity and/or one application under the R&D Activity). Applications for both activities  may include up to three projects. Eligible Applicants interested in applying under both activities must submit two separate applications – one for each activity. The application questions included in the FP&S Activity are different from those in the R&D Activity application. Submissions of duplicate applications may be disqualified.  

Purpose
FP&S Grant Program supports fire departments and non-profit organizations for fire prevention programs and firefighter health and safety research and development. The FP&S Grant Program is separated into the following two activities: Fire Prevention and Safety (FP&S) and Research and Development (R&D). Using a competitive process that is informed by fire service subject matter experts, the Federal Emergency Management Agency (FEMA) awards grants in both activities to applicants whose requests best address the priorities of the FP&S Grant Program. 

NSF X-Labs: Scientific Instrumentation for Sensing and Imaging (Topic 2)

Institutionally Coordinated - contact RDS if you are interested in this funding opportunity // Limit: 2 (lead organization)

SUBJECT TO CHANGE STATEMENT: The terms of this funding opportunity are actively under ORP review and the competition is thus subject to change. The solicitation indicates that academic institutions are not the end goal for this funding. 

Limiting Language 
An eligible organization can submit a maximum of two Written Proposals per Topic Announcement for Phase 0 as a lead organization. Senior/Key Personnel may be listed on a maximum of one Written Proposal per Topic Announcement.

Topic Description

Every revolution in science has been preceded by a revolution in what we can measure, from the telescope to modern Magnetic Resonance Imaging (MRI) machines. Today, the frontier is starved for radically new modalities for sensing and imaging. We cannot watch a non-crystalline enzyme work at atomic resolution, probe the full dynamics of a working synapse, or identify the most reactive surface defect structures on advanced catalytic materials.

NSF X-Labs in this Topic will target specific platform technologies in sensing, imaging and supporting technologies that will form the basis for revolutionary new capabilities in scientific discovery and technology sectors. Teams might, for example, draw on quantum sensing, artificial intelligence (AI)-driven computational imaging, adaptive AI-based sensing algorithms, and/or entirely new modalities to redefine what we consider knowable. 

Examples of relevant, currently unmet R&D challenges may include, but are not limited to: detection of molecular-scale single-reaction events across timescales of femtoseconds to seconds; MRI-free deep-tissue imaging; non-destructive biomolecule microscopy at exquisite resolution; high-sensitivity quantum sensors suitable for operation in a variety of environments; instruments intentionally engineered for next-generation AI training pipelines; and sensors to resolve whole-brain activity at cellular resolution across long timescales. 

An NSF X-Labs Mission in this Topic must be transformative, accelerating breakthrough R&D in scientific instrumentation towards creating or reshaping new lines of research and technologies. Successful teams will overcome technical barriers facing sensing and imaging, develop platform technologies, demonstrate measurable impact on the U.S. science and technology landscape, and position their technologies for widespread use and investment in research and/or other sectors. 

Examples of challenges not considered in scope for this Topic include computational or software solutions without practical integration into an instrumentation system, development of technologies where the impact is narrow and not widely deployable, fundamental research without potential for application in platform technologies, incremental advancement of the state of the art, or advancement of technologies that are already appropriately developed to the point of full-scale commercialization.

Full sponsor guidelines are linked here. 

Upcoming Webinars
Thursday, May 28, 1–2 p.m. Eastern Daylight Time (EDT)
Introduction to NSF X-Labs Funding Opportunity – Scientific Instrumentation for Sensing and Imaging
Register for the May 28 webinar.

Tuesday June 23, 2:30–3:30 p.m. EDT
Q&A for NSF X-Labs – Scientific Instrumentation for Sensing and Imaging
Register for the June 23 Q&A session.

National Center for Construction Safety and Health Research and Translation (U54)

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Limiting Language
Only one application per institution (normally identified by having a unique UEI number) is allowed. As defined in the HHS Grants Policy Statement, applications received in response to the same NOFO generally are scored individually and then ranked with other applications under peer review in their order of relative programmatic, technical, or scientific merit. CDC/NIOSH will not accept any application in response to this NOFO that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application.

Purpose
 
NIOSH is seeking applications from qualified organizations for a National Center for Construction Safety and Health Research and Translation (also known as the NIOSH National Construction Center). Applicants are expected to propose multi-disciplinary approaches for impactful applied and intervention research and hazard identification and controls, to develop partnerships for implementing prevention and intervention activities, and to serve as leaders in research translation and research-to-practice for the protection of construction workers in the United States. The NIOSH National Construction Center will accomplish these goals by 1) integrating and advancing research, 2) translating and disseminating best practices, 3) disseminating information, 4) informing policy, and 5) building capacity. Applicants must describe the occupational health and safety burden(s) addressed in their proposals. In addition, they must link the need for the proposed research and related activities to the planned outputs and outcomes that will help address or alleviate the construction sector burdens described. Applicants should also describe the anticipated impacts and potential outcomes of the proposed research and related activities that will occur during the 5-year project period and beyond.

Funding Type
External Deadline
9/30/2026 (Required LOI); 10/30/2026 (Full Application)

Tuberculosis Research Advancement Centers (TRACs) (P30 Clinical Trial Not Allowed)

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Limiting Language
Only one application per institution (normally identified by having a unique entity identifier (UEI) number or NIH IPF number) is allowed.

No institution may submit, or participate in (as a sub-award), more than one TRAC application.

NOFO Purpose
The purpose of this notice of funding opportunity (NOFO) is to support applications for the Tuberculosis (TB) Research Advancement Centers (TRACs) program. The goal of the TRACs is to develop the next generation of TB researchers and to catalyze multidisciplinary and innovative TB science by providing expertise and resources to facilitate basic and clinical TB research.

Funding Opportunity Goals 
To assist public and private nonprofit institutions and individuals to establish, expand and improve biomedical research and research training in infectious diseases and related areas; to conduct developmental research, to produce and test research materials. To assist public, private and commercial institutions to conduct developmental research, to produce and test research materials, to provide research services as required by the agency for programs in infectious diseases, and controlling disease caused by infectious or parasitic agents, allergic and immunologic diseases and related areas. Projects range from studies of microbial physiology and antigenic structure to collaborative trials of experimental drugs and vaccines, mechanisms of resistance to antibiotics as well as research dealing with epidemiological observations in hospitalized patients or community populations and progress in allergic and immunologic diseases. Because of this dual focus, the program encompasses both basic research and clinical research.