Biomedical, Clinical & Life Sciences

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Goal and Focus  

The goal of these grants is to overcome barriers to the clinical application of new treatment approaches for childhood cancer. A priority is to fund projects that have already shown great promise, but that have a specific funding need to move forward. 

The three main focus areas for this RFP are:  

• Cancer immunotherapy or targeted therapy  

• High-grade brain tumors or other difficult-to-treat pediatric cancers  

• Epigenetic modifying therapy or gene therapy  Applications of novel technologies (e.g. nanotechnology, omics, gene editing, bioinformatics, and AI) in these areas are welcome. 

Eligibility  

• Applications will only be accepted from Children’s Oncology Group member institutions in North  America (no citizenship requirements).  

• Open to PIs at all academic ranks with MD and/or PhD  

• Limit of one application per institution for either the Collaborative or the Individual grant with the  endorsement of the Chief(s) of the Division(s) of Pediatric Hematology-Oncology.  

 

The University of Arizona is not eligible due to an existing award.

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*The first submission may address any cancer type. A second submission is allowed but only for a translational or clinical stage project that primarily focuses on one of the following four cancer types: upper GI, glioblastoma, triple-negative breast cancer, or pancreatic cancer.

The University of Arizona Cancer Center (UACC) is coordinating this limited submission. For more information please contact: UACC-PreAward.

Purpose of the Award
The Mark Foundation Endeavor Awards support collaborative research projects that bring together investigators with diverse areas of expertise to tackle challenges in the prevention, diagnosis, and treatment of cancer. These grants are awarded to teams of three or more investigators to generate and integrate data from diverse lines of research and transform those insights into advances for cancer patients that could not be achieved by individual efforts. Basic, translational, and clinical projects are eligible. The project must seek to address an overarching, urgent scientific question. We welcome projects addressing substantial unmet needs in any type of cancer. We particularly encourage teams with innovative ideas for therapeutic strategies for upper GI, glioblastoma, triple-negative breast cancer, and pancreatic cancer to consider applying in this round.

The University of Arizona is not eligible for this funding opportunity

NIGMS will co-fund applications from higher education institutions that award undergraduate (B.S. or B.A.) and/or graduate degrees in biomedical sciences and have received no more than $6 million dollars per year (total costs) from NIH Research Project Grants (RPGs) in each of the preceding two fiscal years, calculated using NIH RePORTER, at the time of the application.  Applications to be considered must support research aligned with the NIGMS mission. Applications for research capacity building in Institutional Development Award (IDeA)-eligible states will be considered.  

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The mission of The G. Harold and Leila Y. Mathers Foundation is to advance knowledge in the life sciences by sponsoring scientific research that will benefit mankind. The foundation’s grants program seeks to support basic science, ideally with potential translational applications. Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.

For many years the Foundation has enjoyed special recognition in the research community for supporting “basic” scientific research, realizing that true transformative breakthroughs usually occur after a thorough understanding of the fundamental mechanisms underlying natural phenomena. More recently, and with the advent of newer investigative methodologies, technology, and tools, the Foundation now embraces innovative translational research proposals.

The grant duration must be three years. The budget should be reasonable based on the aims of the project. Indirect costs may not exceed 10%. Preliminary Budgets are required during the LOI phase. A detailed budget justification is not required until the proposal phase. The Foundation’s grant award is not intended to be utilized for purchasing capital equipment (“bricks-and-mortar”) for the lab and is intended only to support the actual investigation. The Foundation assumes and expects that capital equipment must be provided by the research institution or university.

Application Guidance:

• Grant budgets cannot exceed $600-750K
• The Foundation primarily supports basic science, ideally with potential translational applications.
• Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.
• Covid-19-related research projects (aims or sub-aims) will not be considered for support.
• Medical imaging technology-related projects and/or electrical engineering technology development projects will not be considered for support.
• Plant Biology Research, Oceanography, Space Exploration. and Global warming-related research will not be considered for support.
• As technology continues to advance, it is apparent that investigations in the area of basic science and translational research may become more and more reliant on collaborative, interdisciplinary projects. It is important to note that any interdisciplinary project proposals may require additional information regarding the collaborator(s)’ achievements and relevant expertise.
• Feedback for declined LOI Requests will not be provided; LOIs or Formal Proposals that have been declined should not be resubmitted at a later date for consideration.
• Renewal applications for the same or related research will not be accorded priority consideration. It is strongly advised that any re-application for grant renewal consider a new direction based on prior research or emphasize some new potential translational aspects and not merely an extension of previously funded research.
• Requests for funding previously federally supported research and/or applications pending federal approval will not be accorded priority consideration.
• Requests for support of clinical trials or drug discovery will not be approved. The Foundation will not support projects which we consider pre-clinical drug development.

Fall 2025

Nominations and Portal Registration due date: September 19, 2025 (Friday, 8 PM EST (5 PM PST)
Nominations can be submitted beginning August 1, 2025.

Due date for LOI applications: October 3, 2025 (Friday, 8 PM EST (5 PM PST) 
Applicants notified of proposal invitation or LOI rejection within one month of the due date. 

Due date for invited formal proposals: December 12, 2025 (Friday, 8 PM EST (5 PM PST) 
Applicants are notified of proposal approval or rejection within 2 ½ months of the due date. 

 *Late nominations and/or registrations will not be approved.
 

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Program Overview
The Searle Scholars Program supports research of outstanding individuals who have recently begun their appointment at the assistant professor level, and whose appointment is their first tenure-track position at a participating academic or research institution. Today, 168 institutions are invited to participate in the Program.

The Program was established at The Chicago Community Trust in 1980 and has been administered by Kinship Foundation since 1996. The Program is funded from the estates of Mr. and Mrs. John G. Searle. Mr. Searle was the grandson of the founder of the world-wide pharmaceutical company, G.D. Searle & Company. It was Mr. Searle's wish that certain funds be used to support "...research in medicine, chemistry, and the biological sciences."

Each year 15 new individuals are named Searle Scholars. Awards are currently set at $100,000 per year for three years. Since its inception, 617 Scholars have been named and over $174 million has been awarded.

Eligibility
The Searle Scholars Scientific Advisory Board is primarily interested in the potential of applicants to make innovative and high-impact contributions to research over an extended period of time.

Applicants for the 2026 competition (awards which will be activated on July 1, 2026) are expected to be pursuing independent research careers in biochemistry, cell biology, genetics, immunology, neuroscience, pharmacology, and related areas in chemistry, medicine, and the biological sciences.

Applicants should have begun their appointment as an independent investigator at the assistant professor level on or after May 1, 2024. The appointment must be their first tenure-track position (or its nearest equivalent).

Institutions which do not have tenure-track appointments should consult with the Scientific Director of the Program regarding eligibility of selected applicants PRIOR to nominating such individuals.

The Searle Scholars Program does not ordinarily support purely clinical research but has supported research programs that include both clinical and basic components. Potential applicants who are unsure if their research is appropriate for our Program are encouraged to examine the research interests of present and former Searle Scholars on this website.

Applicants who were nominated for awards in the previous competition year but were not awarded may still meet the eligibility criteria for the current competition. Institutions should consult with the Scientific Director of the Program regarding renomination of such individuals.

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Limiting Language
Only one application is allowed.

Executive Summary
The National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), invites grant applications for Education and Research Centers (ERCs) that are focused on occupational safety and health (OSH) training. NIOSH is mandated to provide an adequate supply of qualified personnel to carry out the purposes of the Occupational Safety and Health Act, and the ERCs are one of the primary means for meeting this mandate.

ERCs are academic institutions that provide high-quality interdisciplinary graduate and post-graduate training, research training, continuing education, and outreach in the core OSH disciplines of industrial hygiene, occupational health nursing, occupational medicine, and occupational safety, as well as allied disciplines.

Research and research training are integral components of ERCs, with ERC faculty and NIOSH trainees conducting research on issues related to the NIOSH National Occupational Research Agenda (NORA) and emerging issues to advance the OSH field.

NIOSH ERCs have regional presence to ensure that the training and research they support is beneficial to workers across the nation.

ERCs serve as resources for our nation's workforce through continuing education, outreach and strong collaboration with professional associations, worker advocacy groups, businesses, industries, and public health agencies. ERCs work with other institutions and organizations, including Minority Serving Institutions and other NIOSH supported training programs to have a positive impact on worker health, safety, and well-being.

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These grants are not for a specific research project, but rather for personnel (i.e., a clinical research associate) or resources to allow more research to be done. These grants are intended for institutions with the potential to participate significantly more in childhood cancer clinical trials, but which are smaller or have barriers to greater participation due to a lack of resources. Applications to support Clinical Research Associate (CRA) type positions are preferred. Preference is given to institutions with high needs and low philanthropic support in geographical areas where St. Baldrick’s funds are raised. Institutions which do not currently receive other St. Baldrick’s grants are also given preference. (Grant will be $25,000–$50,000.)  

For full eligibility criteria, please see the RFA.