Upcoming

Apply to Internal Competition // Limit: 1 // Tickets Available: 1

Limiting Language
Only one application per institution (normally identified by having a unique UEI or NIH IPF number) is allowed.

Program Description 
The purpose of this notice of funding opportunity (NOFO) is to support applications to continue the Immune Tolerance Network (ITN). The primary objective of the Network is to develop tolerogenic therapies for immune-mediated disorders. The three main clinical areas of work are: 1) Allergic diseases and asthma; 2) Autoimmune diseases; and 3) Immune-mediated consequences of transplantation. The core functions of the ITN include designing, conducting, and sharing the results of clinical trials and performing integrated mechanistic studies.

Full sponsor guidelines are linked here.

Apply to Internal Competition // Limit: 1 // Tickets Available: 1

Limiting Language
Only one application per institution (normally identified by having a unique entity identifier (UEI)) is allowed.

Funding Opportunity Description
The purpose of the National Library of Medicine (NLM) Institutional Training Program in Biomedical Informatics, Data Science, and Artificial Intelligence (AI) is to support pre-doctoral and postdoctoral training for research careers in fields which jointly advance information sciences and data-driven discovery. As the scale and complexity of biomedical and health data continue to grow, there is an increasing national need for a highly skilled workforce capable of developing innovative computational, statistical, and information science approaches to accelerate biomedical discovery and improve health. Graduates of NLM-supported T15 programs are expected to conduct original basic or applied research at the intersection of computer, statistical, and information sciences and one or more biomedical application domains, preparing them for research- and development-oriented roles in academic institutions, not-for-profit research institutes, governmental and public health agencies, biomedical and technology companies, and health care organizations.

Apply to Internal Competition // Limit: 1 // Tickets Available: 1

Limiting Language
Only one application per institution (normally identified by having a unique UEI or NIH IPF number) is allowed.

Purpose
The purpose of this notice of funding opportunity (NOFO) is to support research and/or preclinical development of highly efficacious vaccines against malaria - one of the deadliest mosquito-borne diseases - by capitalizing on recent technological innovations, particularly in structure-based immunogen design, improved formulations, and combination vaccines. The goal is to achieve long-lasting, highly effective protection that can save lives, strengthen public health security in the United States, and serve as a model for, or are potentially effective against, other mosquito-borne diseases. 

Full sponsor guidelines are linked here.

Apply to Internal Competition // Limit: 3 // Tickets Available: 3

Limiting Language 
The Mathers Foundation Grants Program is a limited competition, where eligible organizations may submit up to three (3) institute-nominated Letter of Inquiry (LOI) applications per grant cycle. 

Program Overview
Full sponsor guidelines are linked here.

The mission of The G. Harold and Leila Y. Mathers Foundation is to advance knowledge in the life sciences by sponsoring scientific research that will benefit mankind. The foundation’s grants program seeks to support basic science, ideally with potential translational applications. Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.

For many years the Foundation has enjoyed special recognition in the research community for supporting “basic” scientific research, realizing that true transformative breakthroughs usually occur after a thorough understanding of the fundamental mechanisms underlying natural phenomena. More recently, and with the advent of newer investigative methodologies, technology, and tools, the Foundation now embraces innovative translational research proposals.

The grant duration must be three years. The budget should be reasonable based on the aims of the project. Indirect costs may not exceed 10%. Preliminary Budgets are required during the LOI phase. A detailed budget justification is not required until the proposal phase. The Foundation’s grant award is not intended to be utilized for purchasing capital equipment (“bricks-and-mortar”) for the lab and is intended only to support the actual investigation. The Foundation assumes and expects that capital equipment must be provided by the research institution or university.

Application Guidance:

• Grant budgets cannot exceed $600-750K
• The Foundation primarily supports basic science, ideally with potential translational applications.
• Immunology, microbiome, genomics, structural biology, cellular physiology, neuroscience, etc., are some noteworthy examples of current research support.
• Covid-19-related research projects (aims or sub-aims) will not be considered for support.
• Medical imaging technology-related projects and/or electrical engineering technology development projects will not be considered for support.
• Plant Biology Research, Oceanography, Space Exploration. and Global warming-related research will not be considered for support.
• As technology continues to advance, it is apparent that investigations in the area of basic science and translational research may become more and more reliant on collaborative, interdisciplinary projects. It is important to note that any interdisciplinary project proposals may require additional information regarding the collaborator(s)’ achievements and relevant expertise.
• Feedback for declined LOI Requests will not be provided; LOIs or Formal Proposals that have been declined should not be resubmitted at a later date for consideration.
• Renewal applications for the same or related research will not be accorded priority consideration. It is strongly advised that any re-application for grant renewal consider a new direction based on prior research or emphasize some new potential translational aspects and not merely an extension of previously funded research.
• Requests for funding previously federally supported research and/or applications pending federal approval will not be accorded priority consideration.
• Requests for support of clinical trials or drug discovery will not be approved. The Foundation will not support projects which we consider pre-clinical drug development.

Please note, while RDS and SPS will manage submitting the institutional nomination, it is the responsibility of the selected faculty members to complete the portal registration by the January 28, 2027 at 8pm EST deadline.

Apply to Internal Competition // Limit: 1 // Tickets Available: 1

Limiting Language 
Only one application per institution (normally identified by having a unique entity identifier (UEI) number or NIH IPF number) is allowed

Description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.

To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through investigational new drugs (IND) studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.

Internal Competition Undergoing Peer Review // Limit: 2 // Tickets Available: 0

Limiting Language
Each eligible institution may submit a maximum of two proposals for the 2027–2028 funding cycle.
 

Overview
The ASCENDR Research Program is a competitive, faculty-led program designed to advance research aligned with the U.S. Department of War’s (DoW) science and technology priorities. Through targeted research funding, faculty across HSRU Alliance institutions will lead projects that address real-world defense challenges while engaging graduate students in meaningful research experiences. The program supports the development of innovative solutions in key technical areas and fosters deeper collaboration between academic researchers and the defense enterprise.

Critical Technology Areas
For the 2027–2028 funding cycle, proposed research must contribute to one or more of the six DoW Critical Technology Areas identified for this competition. Proposals may address a Critical Technology Area directly or advance foundational, enabling, or cross-cutting research with a clearly articulated connection to one or more of the areas

1. Applied Artificial Intelligence (AAI)
   Research that advances the effective application of artificial intelligence, machine learning, data analytics, and related computational methods to improve decision-making and operational efficiency. Relevant research may include algorithms, data methods, autonomy, human-machine teaming, modeling and simulation, trustworthy and assured AI, and approaches that enable reliable AI adoption across defense domains.
2. Biomanufacturing (BIO)
   Research that harnesses living systems, biological processes, and bioengineering to produce critical materials, substances, or capabilities at scale. Relevant research may include bioprocess development, synthetic biology, biofabrication, scale-up, quality and reproducibility, and approaches that reduce supply-chain vulnerabilities and strengthen resilience.
3. Contested Logistics Technologies (LOG)
   Research that enables forces to operate and sustain missions when transportation, supply networks, communications, or infrastructure are disrupted, degraded, or denied. Relevant research may include energy storage and power systems, resilient supply networks, predictive logistics, autonomous or distributed resupply, maintenance and sustainment, and production at the point of need.
4. Quantum and Battlefield Information Dominance (Q-BID)
   Research that advances technologies needed to maintain information advantage in degraded or denied environments, including resilient communications, precision navigation and timing, sensing, and electromagnetic-spectrum maneuverability. Relevant research may draw on quantum science and engineering, radio-frequency technologies, photonics, radar and electronic warfare, secure networks, signal processing, and other approaches that improve the availability, accuracy, and survivability of battlefield information.
5. Scaled Directed Energy (SCADE)
   Research that advances scalable and affordable high-energy laser and high-power microwave capabilities for the precise neutralization of threats. Relevant research may include energy sources, materials and components, power and thermal management, beam generation and control, modeling and testing, manufacturability, and approaches that overcome cost and production barriers.
6. Scaled Hypersonics (SHY)
   Research that enables the affordable and scalable development of systems operating at Mach 5 or greater. Relevant research may include propulsion, aerothermodynamics, high-temperature materials and structures, thermal protection, guidance, navigation and control, sensing, modeling and simulation, testing, and manufacturing approaches that improve speed, precision, survivability, and production at scale

Eligibility

The proposal must originate from an HSRU member institution in good standing.

• Principal Investigator and Co-Principal Investigator(s) must be a Research Faculty member or Tenure/Tenure Track Faculty member that is early to mid-career, defined as within the first 8 years of their professional research career.     
• The Principal Investigator must hire and integrate at least one Graduate Research Assistant for this project. The graduate assistant must be enrolled at the start of the project and maintain enrollment eligibility throughout the proposed project.  
• All PIs, Co-PIs, and the graduate assistant working on this project must be U.S. Persons, defined as U.S. born or U.S. Naturalized Citizens.
• The Principal Investigator and Co-PIs must agree to jointly participate in the ASCENDR Leadership Program.

Full sponsor guidelines are linked here.

Apply to Internal Competition // Limit: 1 // Tickets Available: 1

Limited Language
This is a limited submission opportunity: each institution may nominate ONE applicant for this funding opportunity 

Program Overview
At Susan G. Komen®, we are committed to saving lives by meeting the most critical needs in our communities and investing in breakthrough research to conquer deadly and aggressive breast cancers. We are determined to change the unacceptable reality that each year about 43,000 people in the U.S. will die from breast cancer. As part of this goal, we are focused on improving the care and outcomes for people with inflammatory breast cancer (IBC), a rare and highly aggressive form of breast cancer.  

IBC is characterized by tumor cell emboli blocking the breast lymph vessels. This blockage causes inflammatory-like changes in the breast, including swelling and skin reddening. The American Joint Committee on Cancer (AJCC) guidelines define IBC by the rapid onset (less than 6 months) of erythema occupying at least 1/3 of the breast, edema, peau d’ orange (orange peel-like appearance) and/or warmth (with or without an underlying mass), and pathologic confirmation of invasive carcinoma. Although IBC has been recognized as a distinct form of breast cancer for over a century, its etiology and underlying biological mechanisms remain poorly understood. Consequently, no validated, widely adopted IBC-specific biomarkers or targeted therapies exist, and current management is largely informed by evidence from non-IBC breast cancer. This limited understanding of IBC biology remains a significant barrier to the development of more precise diagnostic and therapeutic approaches, highlighting the need for research focused on the unique mechanisms driving the disease. Therefore, the goal of the Inflammatory Breast Cancer (IBC) Research Grant is to support innovative, hypothesis-driven research that advances our understanding of the biological underpinnings of IBC and opens new avenues of investigation into the disease.  

To identify areas where investment could have the greatest impact, the Susan G. Komen-IBCRF IBC Collaborative, in partnership with the Milburn Foundation, convened the Biology of IBC Task Force, a group of IBC researchers and patient advocates. The Task Force identified three broad areas of scientific opportunity that require significant investigation to advance the field: 

• 1. IBC onset and development, including studies focused on the tumor and host microenvironment, epigenetic and proteomic drivers of disease, host genetic factors and biological contributors to health disparities. 

  2. IBC metastatic dissemination, including mechanisms of cell migration and mobility, biological characteristics associated with therapeutic response and the role of tumor and host, epigenetic and proteomic factors in IBC disease progression. 

  3. IBC monitoring and detection, including approaches to detect minimal residual disease (MRD), improve prognostication, assess therapeutic response and advance theragnostic strategies. 

Eligibility 
Applicant/PIs and Institutions must conform to the following eligibility criteria to apply for an Inflammatory Breast Cancer Research Grant. Grants will be awarded to a single Principal Investigator (PI). Co-Principal Investigators (Co-PIs) are not allowed. CoInvestigators are permitted. 
Applicant/PI 

• Must be nominated as the sole Applicant/PI from their institution by the Institution’s Office of Sponsored Programs, Grants Office, or equivalent. This is a limited submission opportunity, and the Applicant/PI cannot self-nominate.  
• Must have a doctoral degree, such as M.D., Ph.D., D.Ph., D.O. or equivalent. 
• Must hold a full-time faculty appointment or have a formal offer letter from the Institution that confirms position and start date by the Full Application due date (January 18, 2027), documented by the Applicant/PI Biosketch.  
• May NOT be the PI of an active Komen Grant that includes specific aims or objectives focused on IBC at the Full Application due date (January 18, 2027).  
• May NOT be the PI of two or more active Komen Grants at the Full Application due date (January 18, 2027) 
• Must ensure that all past Komen-funded Grants are up to date and in compliance with all Komen requirements, e.g., progress and financial report submissions, IRB approvals, etc. by the Full Application due date (January 18, 2027), if applicable. 
• Is not required to be a U.S. citizen or permanent resident. 
• The institution-nominated Applicant/PI may submit only one Letter of Intent in response to this funding announcement.  

Institutionally Coordinated // Limit: 3* 

For additional information, please contact Marie Teemant. 

Limiting Language
Each institution may submit up to three nominations, one in each disciplinary category of Life Sciences, Physical Sciences & Engineering, and Chemical Sciences.

Program Overview
The Blavatnik National Awards for Young Scientists recognize the United States' most promising faculty-rank researchers in Life Sciences, Physical Sciences & Engineering, and Chemical Sciences. One Blavatnik National Awards Laureate in each disciplinary category will receive $250,000 in unrestricted funds, and additional nominees will be recognized as Finalists, and will receive $15,000 in unrestricted funds.

Eligibility
The nominee must:

• Have been born in or after 1985*.
• Hold a doctorate degree (PhD, DPhil, MD, DDS, DVM, etc.).
• Currently hold a tenured or tenure-track academic faculty position, or equivalent, at an eligible institution in the United States.
• Currently conduct research as a principal investigator in one of the disciplinary categories in Life Sciences, Physical Sciences & Engineering, or Chemical Sciences.

Internal Competition Under Peer Review // Limit: 2 // Tickets Available: 1* 

H. Haeger (Education, Competitive Resubmission)

* Please note the number of limited submissions tickets available in this internal competition is subject to change based on the review scores of proposals submitted to the March 2026 deadline. One or both prior applicants may qualify for a competitive resubmission under our limited submissions policies. As of 10/2, we are still awaiting NSF's feedback on one March 2026 proposal. 

Limiting Language
Limit on Number of Proposals per Organization: 2

For a given S-STEM deadline, an institution may submit up to two proposals in which it will be directly involved in providing scholarships. Multiple proposals from an institution must not overlap with regard to S-STEM eligible disciplines. See Additional Eligibility Information below for more details (see IV. Eligibility Information).

Institutions with a current S-STEM award should wait at least until the end of the third year of execution of their current award before submitting a new Track 2 or Track 3 S-STEM proposal focused on students pursuing degrees in the same discipline(s).

Please see the table below for current and pending institutional S-STEM awards and proposals, March 2027 proposals should not overlap with diciplines listed below:

Program Overview 
The main goal of the S-STEM program is to enable academically talented, low-income students to pursue successful careers in promising STEM fields. Ultimately, the S-STEM program seeks to increase the number of academically promising low-income students who graduate with an S-STEM eligible degree and contribute to the American innovation economy with their STEM knowledge. Recognizing that financial aid alone cannot increase retention and graduation in STEM, the program provides awards to institutions of higher education (IHEs) not only to fund scholarships, but also to adapt, implement, and study evidence-based curricular and co-curricular[a] activities that have been shown to be effective in supporting recruitment, retention, transfer (if appropriate), student success, academic/career pathways, and graduation in STEM.

To be eligible, scholars must be domestic low-income students with academic ability, talent, or potential and demonstrated unmet financial need who are enrolled in an associate, baccalaureate, or graduate degree program in an S-STEM eligible discipline. Proposers must provide an analysis that articulates the characteristics and academic needs of the population of students they are trying to serve. NSF is particularly interested in supporting the attainment of degrees in fields identified as critical needs for the Nation. It is up to the proposer to make a compelling case that such a field serves a critical need in the United States.

[a] an activity at a school or college pursued in addition to the normal course of study.

S-STEM Eligible Degree Programs

• Associate of Arts, Associate of Science, Associate of Engineering, and Associate of Applied Science
• Bachelor of Arts, Bachelor of Science, Bachelor of Engineering and Bachelor of Applied Science
• Master of Arts, Master of Science, and Master of Engineering
• Doctoral (Ph.D. or other comparable doctoral degree)

S-STEM Eligible Disciplines

Disciplinary fields in which research is funded by NSF, including technology fields associated with the S-STEM-eligible disciplines (e.g., biotechnology, chemical technology, engineering technology, information technology, etc.).

The following degrees and disciplines are excluded:

• Clinical degree programs, including medical degrees, nursing, veterinary medicine, pharmacy, physical therapy, and others not funded by NSF, are ineligible degrees.
• Programs for STEM teacher certification or licensure currently covered by the Robert Noyce Teacher Scholarship program (NOYCE) are ineligible for S-STEM funding.
• Business school programs that lead to Bachelor of Arts or Science in Business Administration degrees (BABA/BSBA/BBA) are not eligible for S-STEM funding.
• Masters and Doctoral degrees in Business Administration are also excluded.

Proposers are strongly encouraged to contact Program Officers before submitting a proposal if they have questions concerning degree or disciplinary eligibility.

The S-STEM program particularly encourages proposals from 2-year institutions, predominately undergraduate institutions, and urban, suburban, and rural public institutions.

Full sponsor guidelines are linked here.

IMPORTNAT NOTE: 
We are proceeding with our normal internal competition schedule even though there is not currently a live solicitation for the NSF Major Research Instrumentation (MRI) program. We are monitoring the program and will provide updates as they are available. If there are major changes in a new solicitation, we will work with applicants to respond accordingly. 

The deadline to submit pre-proposals has passed, RDS will communicate next steps to applicants once the solicitation is released // Limit: 4 (subject to change, see above) // Tickets Available: 4

Limiting Language
Each performing organization may submit in revised "Tracks" as defined below, with no more than two (2) submissions in Track 1 and no more than one (1) submission in Track 2. For the newly defined Track 3, no more than one (1) submission per competition is permitted. As a result, it is now possible for an institution to submit up to four MRI proposals within the Track limits as described above.

Inclusion as a funded subawardee on a development proposal at a level in excess of 20% of the total budget requested from NSF, or as a funded subawardee, when allowed, on any acquisition proposal, will be counted against an organization's proposal submission limit. If you plan to partner at a level in excess of 20%, please notify RDS by the internal deadline. 

Program Description

The NSF Major Research Instrumentation Grant is awaiting a new solicitation. The old solicitation for the program is linked here. The program page is linked here. Details from the previous solicitation are included below.

The Major Research Instrumentation (MRI) Program (MRI Program Website) serves to increase access to multi-user scientific and engineering instrumentation for research and research training in our Nation's institutions of higher education and not-for-profit scientific/engineering research organizations. An MRI award supports the acquisition of a multi-user research instrument that is commercially available through direct purchase from a vendor, or for the personnel costs and equipment that are required for the development of an instrument with new capabilities, thereby advancing instrumentation capabilities and enhancing expertise for instrument design and fabrication at academic institutions. MRI instruments are, in general, too costly and/or not appropriate for support through other NSF programs.

MRI provides support to acquire critical research instrumentation without which advances in fundamental science and engineering research may not otherwise occur. MRI also provides support to obtain next-generation research instruments by developing instruments with new capabilities that open new opportunities to advance the frontiers in science and engineering research. Additionally, an MRI award is expected to enhance research training of students who will become the next generation of instrument users, designers and builders.

An MRI proposal may request from NSF up to $4 million for either acquisition or development of a research instrument. Each performing organization may submit in revised "Tracks" as defined below, with no more than two (2) submissions in Track 1 and no more than one (1) submission in Track 2. For the newly defined Track 3, no more than one (1) submission per competition is permitted. As a result, it is now possible for an institution to submit up to four MRI proposals within the Track limits as described above.

• Track 1: Track 1 MRI proposals are those that request funds from NSF greater than $100,0001 and less than $1,400,000.
• Track 2: Track 2 MRI proposals are those that request funds from NSF greater than or equal to $1,400,000 up to and including $4,000,000.
• Track 3: Track 3 MRI proposals are those that request funds from NSF greater than or equal to $100,0001 and less than or equal to $4,000,000 that include the purchase, installation, operation, and maintenance of equipment and instrumentation to conserve or reduce the consumption of helium. Institutions may submit no more than one Track 3 proposal. Submission of a Track 3 proposal does not impact limits that apply for Track 1 and Track 2 proposals.

Cost sharing requirements for new awards in the MRI Program are waived for a period of 5 years beginning with the FY 2023 MRI competition. Institutional submission limits for Track 1, Track 2 and Track 3 proposals remain.