Completed

No applicants// Limit: 1 // Tickets Available: 1 

The Music Recording Program's objective is to increase the public's knowledge of and appreciation for contemporary American concert music and contemporary jazz through the documentation and distribution of commercial recordings.

Limit: 1 // PI: G. Sutphin (Molecular and Cellular Biology)

The University of Arizona Cancer Center (UACC) coordinates the internal selection process for this funding program, for more information please contact UACC-PreAward.

MKAF is currently accepting applications for innovative grants for translational research of cancers affecting women, including but not limited to breast, cervical, endometrial, ovarian, uterine or cancers predominantly affecting women. Grants will be awarded in the amount of $100,000 over a two- year period. PI must commit a minimum 5% effort.

No limit per institution* // 

*Eligibility note: PO has confirmed that the limitation applies to the lead PI, not the institution. That is, DOE wll accept multiple applications from a specific institution, but there can be only one application from an individual who is the lead PI. That individual could be a co-PI/collaborator on another submission from that same institution or on an application that is led by someone else at another institution.

The BER ESS program goal is to advance an integrated, robust, and scale-aware predictive understanding of terrestrial systems and their interdependent microbial, biogeochemical, ecological, hydrological, and physical processes. To support this goal, the program uses a systems approach to develop an integrative framework to elucidate the complex processes and controls on the structure, function, feedbacks, and dynamics of terrestrial systems, that span from molecular to global scales and extend from the bedrock through the soil, rhizosphere, and vegetation to the atmosphere. The ESS program scope advances foundational process knowledge with an emphasis on understudied ecosystems. Supported research emphasizes ecological and hydro-biogeochemical linkages among system components and characterization of processes across interfaces (e.g., terrestrial-aquatic, coastal, urban) to address key knowledge gaps and uncertainties across a range of spatial and temporal scales. Incorporation of scientific findings into process and system models is an important aspect of the ESS strategy, both to improve predictive understanding as well as to enable the identification of new research questions and directions.

Application Types:

Standard – Standard applications are solicited for research projects that may extend up to three years’ duration addressing a research project objective(s) associated with SRA #1 or SRA #2, as described below in this FOA. Standard applications must include significant new field experiments as part of the proposed activities, use observations and experimental outcomes to inform and/or improve models in a ModEx approach, and advance the understanding of ecosystem and/or watershed systems. Projects focused primarily on modeling or model development and/or those lacking substantial new empirical data collection are out of scope. Standard applications should have budgets commensurate with the scope of work (but no more than $1,000,000 in total costs); applications do not have to be proposed at the award ceiling but can and should include smaller-scope research applications with commensurate budgets. The potential impact, probability of success, and the risk-reward balance will be considered when making funding decisions.

Synthesis – Only Synthesis applications are solicited for SRA #3. Synthesis applications should propose new science that is focused on meta-analysis and synthesis research efforts that address development and testing of ESS-relevant hypotheses using existing data, and that have the potential for high impact regarding ESS research priorities. Synthesis awards will have a duration of up to two years and an award ceiling of $400,000 in total costs. Synthesis applications should target innovative questions that can be addressed by both interrogating and integrating existing data to address key knowledge gaps that are relevant and transferable across ecosystems and/or watershed systems. Synthesis applications may not request funding for collection of new data or field research, support for field-related supplies or equipment, travel to or maintenance of field sites or research facilities, or operational support for research networks.

No applicants// Limit: 1 // Tickets Available: 1

UArizona may submit one pre-application.

AHA Membership Requirement: Any individual applying as a Center Director or a Project Principal Investigator (PI) must be an AHA Professional Member before submitting a full proposal. (Membership is not required to submit a pre-proposal.) Join or renew when preparing an application in ProposalCentral, online, or by phone at 301-223-2307 or 800-787-8984. Membership processing may take 3-5 days; do not wait until the application deadline to renew or join.

Required Pre-Proposal 

Each Center Director is required to send a pre-proposal USE THIS LINK to provide the following:

• Name and institution of the Center Director and each Project PI
• Center title, and title and performance site of each proposed project

If required, the mechanism through which partnering requirements are being met. See “Additional Expectations and Opportunities” and “Institutional Eligibility/Location of Work” sections.

As part of the required Pre-Proposal, if the submitting institution or a partnering institution is not a research-intensive institution of higher learning, the lead for that institution must upload a letter from a Senior Institutional Official (e.g., president, provost, dean, etc.) indicating they meet the definition of a non-research-intensive institution as stated in the “Additional Expectations and Opportunities” section. 

AHA staff will review for compliance. A non-complying institution will not be permitted to submit a full proposal. This administrative review is part of the Pre-Proposal process, which is required and, though rare, may prevent an applicant from moving forward. Even though the Pre-Proposal is required, each Center and Project applicants should begin planning and designing their applications before the Pre-Proposal deadline to maximize the amount of time available to develop their full proposal.

Purpose
The American Heart Association (AHA) announces this Request for Proposals for the Strategically Focused Research Network (SFRN) on Inflammation in Cardiac and Neurovascular Disease.

THE ROLE OF INFLAMMATION IN CARDIAC AND NEUROVASCULAR DISEASE

Throughout the body, inflammation plays a crucial role in maintaining tissue homeostasis and initiating appropriate immune responses against pathogens or injury. However, dysregulation of inflammatory processes can lead to detrimental effects, contributing to the development and progression of many disease states, such as autoimmune conditions, cancer, diabetes, kidney disease and liver disease.1

The heart and nervous system are also subject to disease with dysregulation of the inflammatory system. Inflammatory myocarditis, characterized by inflammation of the myocardium, is more likely to occur in males compared to females.2 It is most commonly triggered by viral infection; triggering viruses include adenoviruses, enteroviruses, parvoviruses and coronaviruses (including SARS-CoV-2), among others.3  Less commonly, myocarditis is caused by bacterial or fungal infection or autoimmune diseases.  Of more recent note, it was discovered during the COVID-19 pandemic that vaccines developed against SARS-CoV-2, particularly those using mRNA technology, elicited myocarditis in a subset of vaccine recipients.4 The highest incidence (approximately 50 / 100,000) was found in men under 40. 

Myocarditis can be subclassified based on a number of characteristics. The most prominent symptoms are chest pain and dyspnea,5 and in many cases, myocarditis may resolve on its own. One notable exception is fulminant myocarditis, a rare and severe form of myocarditis that is responsible for a high proportion of cardiac-related deaths in young individuals.6 Acute myocarditis is defined as that for which symptoms are of recent onset, generally within a month or so. Inflammatory processes associated with myocarditis, such as infiltration of immune cells, release of pro-inflammatory cytokines, and oxidative stress, can lead to myocyte damage, fibrosis, and impaired contractility.3,7-8 Myocarditis that is associated with cardiac dysfunction and remodeling of the ventricle is referred to as inflammatory cardiomyopathy, a condition that is typically irreversible. It may result in arrhythmias, ventricular dysfunction or heart failure and requires lifelong therapy and/or heart transplant.

Within the nervous system, inflammation has been implicated in an array of pathologies, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.9-10 Inflammation also plays a prominent role in stroke.11-13  A robust neuroinflammatory response is initiated following an ischemic event. Sex differences are also observed with stroke, with the risk being higher for females than males.14 The primary cause of this neuroinflammation is the activation of immune cells in the brain, including microglia and astrocytes. These cells are responsible for defending the brain against pathogens and injuries. However, under certain conditions, they can become overactivated and release inflammatory molecules. Neuroinflammation can have both beneficial and detrimental effects. In acute situations, neuroinflammation helps clear pathogens, promote tissue repair, and support the restoration of normal brain function. However, chronic or excessive neuroinflammation can damage neurons, impair synaptic communication, break down the blood-brain barrier, and disrupt the delicate balance of the brain's environment.11

CARDIOTOXICITY 
Cardiotoxicity describes a condition wherein a decrease in cardiac function results from administration of drugs or other agents. Currently, the term is largely identified with changes in cardiovascular function resulting from treatment with a number of cancer therapies. Whereas a decrease in left ventricular ejection fraction is the cardiac parameter most closely aligned with cardiotoxicity, additional cardiac effects (e.g., left ventricular systolic dysfunction, angina, and acute coronary syndrome) may also be characterized as cardiotoxicity.15 

There are several potential mechanisms underlying cardiotoxicity of chemotherapeutic agents, including inflammation. For example, use of chemotherapeutics of the anthracycline class, widely prescribed because of their efficacy against both solid and hematologic tumors, is associated with a high incidence of cardiotoxicity.16 Despite this effect of anthracyclines being described decades ago, the mechanism(s) underlying cardiotoxicity are not fully elucidated. Studies in more recent years do suggest, however, that at least part of the cardiotoxic actions of anthracyclines are related to inflammation.17 In addition, pre-clinical studies assessing effects of anti-inflammatory agents against anthracycline-induced cardiotoxicity have shown favorable results.18-19  Targeting inflammation thus holds promise for preventing or mitigating cardiotoxic effects of this class of chemotherapeutic. 

More contemporary cancer treatments also elicit adverse cardiac effects. Immune checkpoint inhibitors (ICIs), a new and promising class of anti-cancer drugs, may elicit a severe form of myocarditis.20 Whereas the incidence is relatively low, the mortality rate is high, due in part to the fact that many individuals present with a fulminant-like form of myocarditis. The mechanism underlying ICI-induced myocarditis remains unclear. The promise of this new class of cancer treatment will not be fully realized unless the mechanism is identified, which will facilitate therapeutic strategies to prevent or mitigate this severe adverse effect.   

While our understanding of the role inflammation plays in cardiac and brain dysfunction has grown considerably in recent years, several hindrances remain that preclude improved recognition and treatment of these conditions. For instance, significant gaps remain in understanding of the downstream signaling events and potential crosstalk; development of new animal and in vitro models would support these needs. In addition, notable opportunities for optimization of diagnostic capabilities exist, such as identification and assessment of biomarkers with improved specificity and development of improved imaging techniques. Clinical trials designed to assess outcomes more specifically for distinct types and/or stages of inflammatory conditions are also needed. 

 Limit: 1  // PI:  M. S. Austin Cantu (NAP-Education (SNAP-Ed) and the Expanded Food and Nutrition Education Program (EFNEP))

Only one application per institution is allowed.

The CFPCGP is intended to bring together stakeholders from distinct parts of the food system and to foster understanding of national food security trends and how they might improve local food systems. Understanding that people with low incomes experience disproportionate access to healthy foods, projects should address food and nutrition security, particularly among our nation’s most vulnerable populations. Nutrition security is defined as having consistent access, availability, and affordability of foods and beverages that promote well-being. Applications from organizations that address food insecurity in rural, tribal, and underserved communities are encouraged. 

Limit: 1 // PI: C. Laskowski (College of Law)
 

The Humanities Research Centers on Artificial Intelligence program aims to support a more holistic understanding of artificial intelligence (AI) in the modern world through the creation of new humanities research centers on artificial intelligence at eligible institutions. Centers must focus their scholarly activities on exploring the ethical, legal, or societal implications of AI.  

A Center is a sustained collaboration among scholars focused on exploring a specific topic. Successful applicants will examine the humanities implications of AI through two or more related scholarly activities. Centers must be led by scholars in the humanities or humanistic social sciences, but should include scholars from multiple disciplines. Scholars may come from one or more institutions. NEH welcomes international collaboration, but scholars at U.S. institutions must contribute significantly to the project. This program is for establishing new Centers; existing Centers and Institutes are not eligible in this competition.

In addition to the establishment of a sustainable Center, your project should engage in at least two activities that support research into the ethical, legal, or societal implications of AI. Appropriate activities may include but are not limited to: collaborative research and writing efforts; workshops or lecture series; education and mentoring; and the creation of digital tools to increase or advance scholarly discourse about AI.  

No applicants // Limit: 1 // Tickets Available: 1 

The St. Baldrick's Foundation is a volunteer and donor powered charity committed to supporting the most promising research to find cures for childhood cancers and give survivors long and healthy lives.This three (3) year award, with an option for two (2) additional years based on progress, is to train researchers from low- and middle- income countries (as classified by the World Bank) to prepare them to fill specific stated needs in an area of childhood cancer research upon returning to their country of origin. Up to $110,000/year, three-year minimum.

No applicants  // Limit: 1 // Tickets Available: 1 

The St. Baldrick's Foundation is a volunteer and donor powered charity committed to supporting the most promising research to find cures for childhood cancers and give survivors long and healthy lives.The Scholar (Career Development) Award is meant to help develop the independent research of highly qualified individuals still early in their careers.  Up to $110,000/year, three-year minimum.

No applicants  // Limit: 1 // Tickets Available: 1 

The St. Baldrick's Foundation is a volunteer and donor powered charity committed to supporting the most promising research to find cures for childhood cancers and give survivors long and healthy lives.
These grants are for specific two-year research projects which are hypothesis driven and may be either laboratory, clinical, or epidemiological in nature. Grants will be $100,000/year or less.

Limit: 1  // PI:  H. Monroe (Center for Recruitment and Retention of Mathematics Teachers)

The Socker Foundation invests in Literacy and STEAM-focused programming to educate students to read and write to teach students to think critically and creatively with a design and entrepreneurial mindset. Targeted grades include Pre-K - Eighth. The Stocker Foundation will partner with organizations that can effectively and realistically address the following areas of interest:

• Development of foundational reading and writing skills.
• Implementation of cross-disciplinary and project-based learning through STEAM.
• Safety-net services that ensure students are healthy, engaged, supported, and challenged, removing barriers to learning and academic achievement.  A small percentage of available funding per community will be considered.

For more information, please contact: Jennifer Carter,JD.