National Institutes of Health (NIH)

Institutionally Coordinated

• Submit a pre-proposal for the Shared Instrumentation Grant Program on Arizona Cultivate
• Submit a pre-proposal for the High-End Instrumentation Grant Program on Arizona Cultivate

ORIP's S10 Instrumentation Grant Programs support purchases of state-of-the-art commercially available instruments to enhance research of NIH-funded investigators. Instruments that are awarded are typically too expensive to be obtained by an individual investigator with a research project grant. Every instrument awarded by an S10 grant is to be used on a shared basis, which makes the programs cost-efficient and beneficial to thousands of investigators in hundreds of institutions nationwide.

To be eligible for an S10 award, an institution must identify three or more principal investigators with active NIH research awards who demonstrate a substantial need for the requested instrument. Matching funds are not required. Types of instruments supported by S10 funding include, but are not limited to, X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-analyzers, and biomedical imagers.

Active RFPs are: 

• Basic Instrumentation Grant Program (BIG) – University of Arizona is not eligible 
• Shared Instrumentation Grant Program (SIG) – The SIG Program funds grant awards in the $50,000 to $600,000 range.
• High-End Instrumentation Grant Program (HEI) – The HEI Program funds grant awards in the $600,001 to $2,000,000 range.

There is no restriction on the number of applications an institution can submit to the SIG and/or High-End HEI Grant Programs. However, institutional internal coordination is required for concurrent SIG or HEI applications to verify each proposal is requesting different types of equipment.

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D. Bhattacharya 

NIH recognizes that modern physical infrastructure is necessary for the conduct of cutting-edge research or support specialized breeding operation. Dedicated space is required to house specialized equipment and to carry out experimental protocols. Equipment that enables automation and husbandry of the breeding facility, enhances modern operation, allows telemetry for field/corral monitoring, facilitates social behavioral interactions may be eligible under this NOFO. The scope of individual applications will vary and depend on the currently available infrastructure at the applicant institution, as well as the present and anticipated HIV/AIDS research needs. Requests must be justified by the needs for expanding the breeding capacity for support of HIV/AIDS research. The project, when completed, is expected to provide significant long-term cost-effective support for HIV/AIDS research, bringing the capacities and capabilities to a new level. Consequently, the applicant institution should demonstrate future-looking commitments towards the facility and HIV/AIDS research therein, by attaching a letter of support from a high-ranking institutional official.

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The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on:

• Courses for Skills Development
• Research Experiences
• Mentoring Activities

The fully integrated educational activities should prepare undergraduate students from diverse backgrounds, including those from groups underrepresented in biomedical and behavioral sciences, to enter Ph.D. degree programs in the neurosciences. To accomplish this goal, this initiative will provide institutional awards to develop neuroscience research education programs comprised of collaborative partnerships integrated across different educational institution types.

Each partnership must include:
a) one or more institutions that either: 1) have a historical and current mission to educate students from any of the populations that have been identified as underrepresented in biomedical research as defined by the National Science Foundation (NSF), see http://www.nsf.gov/statistics/wmpd/) (i.e., African Americans or Blacks, Hispanic or Latino Americans, American Indians, Alaska Natives, Native Hawaiians, U.S. Pacific Islanders, and persons with disabilities) or 2) have a documented track record of recruiting, training and/or educating, and graduating underrepresented students as defined by NSF (see above), which has resulted in a historically documented contribution by the institution to the national pool of graduates from underrepresented backgrounds who pursue biomedical research careers;
b) a research-intensive institution that has an established neuroscience or neuroscience-related program;
c) integrated curriculum/academic enhancement and research experience activities designed to increase participants' preparation to enter doctoral programs in the neurosciences; and
d) well-described plans to provide early communication and interaction between participating students and graduate neuroscience programs across the country.

Components of Participating Organizations:
National Institute of Neurological Disorders and Stroke (NINDS)
National Eye Institute (NEI)
National Institute on Aging (NIA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of Mental Health (NIMH)
National Center for Complementary and Integrative Health (NCCIH)
All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
Office of Behavioral and Social Sciences Research (OBSSR)

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NIGMS will accept only one application per eligible organization.

The goal of the Bridges to the Doctorate Research Training Program is to develop a diverse pool of scientists earning a Ph.D. who have the skills to successfully transition into careers in the biomedical research workforce. This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical training and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation.

This FOA does not allow appointed trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

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Only one application per institution (normally identified by having a unique NIH Institutional Profile Number, IPF) is allowed.

The NIH Research Education Program (UE5) supports research education activities in the mission areas of the NIH. The overarching goal of this UE5 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research. 

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on:

• Courses for Skills Development
• Mentoring Activities

The goal of the MOSAIC Research Education Award (UE5) is to support educational activities for MOSAIC K99/R00 scholars that will equip them with the professional skills, and provide them with the appropriate mentoring opportunities and professional networks to allow them to transition into, advance, and succeed in independent, tenure-track or equivalent research-intensive faculty careers. Awardee Organizations must provide career development and mentoring activities aligned with and appropriate for the disciplinary backgrounds of scholars supported through the MOSAIC K99/R00 program. Areas of programmatic need will be indicated through Notices of Special Interest (NOSIs) released annually by NIH. Applications that do not address the program areas of need specified in the NOSI will be considered non-responsive and will not be reviewed.

Components of Participating Organizations:
National Institute of General Medical Sciences (NIGMS)
National Eye Institute (NEI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
National Center for Complementary and Integrative Health (NCCIH)
All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
Office of Behavioral and Social Sciences Research (OBSSR)
Sexual and Gender Minority Research Office (SGMRO)

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This Notice of Funding Opportunity (NOFO) invites applications for the Claude D. Pepper Older Americans Independence Centers (OAICs) award. The goal of the OAIC program is to establish centers of excellence in geriatrics research and research education to increase scientific knowledge leading to better ways to maintain or restore independence in older persons. OAIC awards are designed to develop or strengthen programs that focus on, and sustain progress in, a key area of aging research related to the mission of the OAIC program.

Area of Focus

To achieve the objectives listed above, each OAIC should promote a sustained research program in an area of focus through which the Center will accomplish the innovation, leadership, collaboration, and research education functions described above. It is crucial to the design of an OAIC to identify an important research area to be addressed, to specify the goals to be achieved within the five-year OAIC award period, to provide a plan to reach these goals, and to outline a method to evaluate progress toward these goals during the course of the OAIC award. The selection of core activities (see below) should follow from these considerations.

An OAIC may select an area of research focus from a broad range of topics, including, but not limited to, the following:

• Aging-related issues concerning a specific condition contributing to loss of independence in older persons (e.g., role of aging changes in the etiology of the condition; special issues in the diagnosis, treatment, or prevention of the condition in old age; complications, disability, or symptoms from the condition found principally in older persons).
• Causes, assessment, prevention, and treatment (including rehabilitation) of a specific type of disability in older persons.
• Causes, prevention, and treatment of geriatric syndromes (e.g., sarcopenia, falls, incontinence) that are related to multiple pathologies and/or disabilities.
• Specific aging-related physiologic changes, other risk factors, and/or interventions (e.g., physical activity) that affect risk for multiple conditions or disabilities in old age.
• Interactions of multiple diseases, disabilities, and interventions (e.g., medications) in older persons and their relationship to risk of morbidity, progression of disability, and efficacy of prevention or treatment strategies.
• Factors contributing to amelioration or delay of multiple deleterious aging changes by modulating risk factors or fundamental aging mechanisms.

In fiscal year 2025, NIA intend to commit approximately $6.5 million to fund 5 competing general awards and $1.3 million to fund 1 competing ADRD award. The maximum project period is 5 years.

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Only one application per institution is allowed. 

The purpose of this notice of funding opportunity is to invite Institutional Network Awards (U2C-TL1) to cultivate a highly integrated cohort of trainees and early career investigators and to develop career development resources to accelerate kidney, urologic, and hematologic research. To maximize integration and promote a true trainee community, Institutions are invited to submit a single, unified U2C-TL1 application to engage, recruit, prepare, and sustain the next generation of scientists able to contribute to advancing research in kidney, urology, and hematology. Applications representing multiple institutions within a single metropolitan area are strongly encouraged (see Section III.3). Successful awardees are expected to relinquish all active T32s supported by the NIDDK, Division of Kidney, Urologic, and Hematologic Diseases (KUH) at the time of the U2C-TL1 award.

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Only one application per institution is allowed.

This Funding Opportunity Announcement (FOA) invites applications from institutions proposing to establish, or renew, an Alzheimer's Disease Research Center (ADRC).

NIA-designated ADRCs serve as a national resource for research on the nature of Alzheimer’s disease (AD) and AD-related dementias (ADRD) and the development of more effective approaches to prevention, diagnosis, care, and therapy. They create shared resources that support dementia-relevant research, and they collaborate and coordinate their research efforts with other NIH-funded programs and investigators. 

Applications may request a budget of up to $2.925 million in direct costs per year.

The maximum project period is 5 years.

Areas of Interest

The objective of NIA's ADRC Program is to foster highly interactive, cutting-edge AD/ADRD research through core services that seek to accomplish the following:

• Create an environment that supports innovative multidisciplinary, inclusive research that has a significant impact on the field of dementia research and treatment;
• Foster interdisciplinary collaborations, especially in emerging areas of research, to catalyze new ideas and scientific approaches;
• Attract, educate and/or train, and retain a group of early stage investigators and investigators new to dementia research that is richly diverse in backgrounds, and academic and technical disciplines;
• Translate scientific discoveries from bench to bedside to community that improve public health and include validation and effectiveness measures;
• Provide rapid and broad sharing of analytic and research tools, as well as data, as appropriate and as consistent with achieving the goals of the program; and
• Enhance dementia-related research education opportunities for people living with dementia, their care partners, students, scientists, and clinicians.

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Only one application per institution is allowed.

This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK.  The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases within the NIDDK's mission.  DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner.  Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of the NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding. 

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

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Only two applications per institution (normally identified by having a Unique Entity Identifier (UEI) number or NIH IPF number) are allowed.

The NIH Director's Early Independence Award supports rigorous and promising investigators who wish to pursue independent research soon after completion of their terminal doctoral degree or post-graduate clinical training, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIH’s Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply. Applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director's Early Independence Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

Requirements:

• Single PD/PI: Only single PD/PI applications are allowed. Multiple PD/PIs applications will not be accepted. Only the PD/PI may be listed as a Senior/Key Person and provide a Biographical Sketch.
• Citizenship: U.S. citizenship is not required. For non-U.S. citizens, the applicant institution is responsible for ensuring the PD/PI's U.S. visa status will allow them to conduct the proposed research at the applicant institution for the entire project period.
• Degree Receipt Date: The receipt date of the PD/PI’s terminal doctoral degree or end of post-graduate clinical training must be between May 1, 2023, and September 30, 2025. The degree receipt date is that which appears on the official transcript for the degree. The end of post-graduate clinical training includes residency and fellowship periods. At the time of award, either:

1. The PD/PI must have received a PhD, MD, DO, DC, DDS, DVM, OD, DPM, ScD, EngD, DrPH, DNSc, ND (Doctor of Naturopathy), PharmD, DSW, PsyD, or equivalent doctoral degree from an accredited domestic or foreign institution (it is the responsibility of the sponsoring institution to determine if a foreign doctoral degree is equivalent).
2. Or an authorized official of the degree-granting or training institution must certify that all degree requirements have been met and that the receipt date of the degree (as will appear on the transcript) will be before September 30, 2025. An authorized official of the host institution must certify that the PD/PI will be able to conduct independent research at the institution at the time of the project start date.

• Post-doctoral Experience: The PD/PI must not have served as a post-doctoral fellow for more than 12 months following a previous, non-terminal doctoral degree (this only applies to PD/PIs with multiple doctoral degrees who served in a 12+ month post-doctoral fellowship before their terminal degree).
• Level of Effort: In the first and second years of the project period, the PD/PI must commit at least 9.6 person-months of effort to the Early Independence Award project each year (80% effort per year). In years 3-5 of the project period, the PD/PI may reduce their effort on the Early Independence Award project but must still conduct at least 9.6 person-months of general independent research each year (80% effort per year). General independent research includes the effort spent on the Early Independence Award project and any other independent research projects the PD/PI is working on.
• Non-independence at Time of Application: Individuals are eligible only if they do not have research independence at the time of application submission. Research non-independence is defined functionally rather than by position title and must have all the following characteristics:
  1. The PD/PI's current research agenda is set through concurrence with mentors.
  2. The PD/PI's research is funded primarily through support to other investigators (mentored fellowships such as NIH F31 or F32 Fellowships or NSF Graduate Research Fellowships do not preclude eligibility).
  3. The PD/PI does not have any space assigned directly by the institution for the conduct of their research.
  4. The PD/PI cannot apply for an NIH R01 grant without a special waiver or exemption from the institution according to institutional policy.

Though PD/PIs must not be functionally independent at the time of application submission, they may become functionally independent prior to time of award and still retain eligibility.

• Independent Research Position: An independent research position at a host institution is required, and the PD/PI must be able to begin independent research by the project start date. The position need not be permanent or tenure-track and may be contingent upon receipt of the Early Independence Award. Prospective PD/PIs should contact appropriate institutional leaders to seek an appointment to an independent research position. Alternatively, institutions may actively recruit eligible scientists to apply for support through this initiative. In either case, the institution is expected to provide substantial support to the PD/PI as detailed in the Facilities & Other Resources section. To foster independence, PD/PIs may benefit from being hosted by an institution at which they have not previously studied or trained.
• Career Awards: PD/PIs may apply for a research career development (K) award and DP5 at the same time, but NIH policy prohibits scientific overlap. A PD/PI may not hold a DP5 and career development award concurrently: The career development award must be relinquished to receive the DP5.
• Site Visit: NIH staff will conduct a one-time site visit at the end of the first year to assess the PD/PI's progress and to ensure they are receiving the institutional resources and support outlined in the application. NIH staff will meet with the PD/PI, lab personnel, mentors, faculty, and institutional leadership. Failure to provide independence and/or support may lead to NIH actions, including reduction of funds.

Awards will be for up to $250,000 in direct costs per year, plus applicable Facilities and Administrative (F&A) costs.