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This Notice of Funding Opportunity (NOFO) invites applications for the Claude D. Pepper Older Americans Independence Centers (OAICs) award. The goal of the OAIC program is to establish centers of excellence in geriatrics research and research education to increase scientific knowledge leading to better ways to maintain or restore independence in older persons. OAIC awards are designed to develop or strengthen programs that focus on, and sustain progress in, a key area of aging research related to the mission of the OAIC program.

Area of Focus

To achieve the objectives listed above, each OAIC should promote a sustained research program in an area of focus through which the Center will accomplish the innovation, leadership, collaboration, and research education functions described above. It is crucial to the design of an OAIC to identify an important research area to be addressed, to specify the goals to be achieved within the five-year OAIC award period, to provide a plan to reach these goals, and to outline a method to evaluate progress toward these goals during the course of the OAIC award. The selection of core activities (see below) should follow from these considerations.

An OAIC may select an area of research focus from a broad range of topics, including, but not limited to, the following:

• Aging-related issues concerning a specific condition contributing to loss of independence in older persons (e.g., role of aging changes in the etiology of the condition; special issues in the diagnosis, treatment, or prevention of the condition in old age; complications, disability, or symptoms from the condition found principally in older persons).
• Causes, assessment, prevention, and treatment (including rehabilitation) of a specific type of disability in older persons.
• Causes, prevention, and treatment of geriatric syndromes (e.g., sarcopenia, falls, incontinence) that are related to multiple pathologies and/or disabilities.
• Specific aging-related physiologic changes, other risk factors, and/or interventions (e.g., physical activity) that affect risk for multiple conditions or disabilities in old age.
• Interactions of multiple diseases, disabilities, and interventions (e.g., medications) in older persons and their relationship to risk of morbidity, progression of disability, and efficacy of prevention or treatment strategies.
• Factors contributing to amelioration or delay of multiple deleterious aging changes by modulating risk factors or fundamental aging mechanisms.

In fiscal year 2025, NIA intend to commit approximately $6.5 million to fund 5 competing general awards and $1.3 million to fund 1 competing ADRD award. The maximum project period is 5 years.

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Only one application per institution is allowed.

This Funding Opportunity Announcement (FOA) invites applications from institutions proposing to establish, or renew, an Alzheimer's Disease Research Center (ADRC).

NIA-designated ADRCs serve as a national resource for research on the nature of Alzheimer’s disease (AD) and AD-related dementias (ADRD) and the development of more effective approaches to prevention, diagnosis, care, and therapy. They create shared resources that support dementia-relevant research, and they collaborate and coordinate their research efforts with other NIH-funded programs and investigators. 

Applications may request a budget of up to $2.925 million in direct costs per year.

The maximum project period is 5 years.

Areas of Interest

The objective of NIA's ADRC Program is to foster highly interactive, cutting-edge AD/ADRD research through core services that seek to accomplish the following:

• Create an environment that supports innovative multidisciplinary, inclusive research that has a significant impact on the field of dementia research and treatment;
• Foster interdisciplinary collaborations, especially in emerging areas of research, to catalyze new ideas and scientific approaches;
• Attract, educate and/or train, and retain a group of early stage investigators and investigators new to dementia research that is richly diverse in backgrounds, and academic and technical disciplines;
• Translate scientific discoveries from bench to bedside to community that improve public health and include validation and effectiveness measures;
• Provide rapid and broad sharing of analytic and research tools, as well as data, as appropriate and as consistent with achieving the goals of the program; and
• Enhance dementia-related research education opportunities for people living with dementia, their care partners, students, scientists, and clinicians.

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Only one application per institution is allowed.

This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK.  The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases within the NIDDK's mission.  DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner.  Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of the NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding. 

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

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Only one application per institution is allowed. 

This Notice of Funding Opportunity (NOFO) invites applications from institutions/organizations that propose to establish core centers that are part of an integrated and existing program of nutrition and/or obesity research. The Nutrition Obesity Research Centers (NORC) program is designed to support and enhance the national research effort in nutrition and obesity. NORCs support three primary research-related activities: Research Core services, a Pilot and Feasibility (P and F) program, and an Enrichment program. All activities pursued by Nutrition Obesity Research Centers are designed to enhance the efficiency, productivity, effectiveness, and multidisciplinary nature of research in nutrition and obesity.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Eligibility Requirements

Because a NORC has a large and complex administrative structure, the PD/PI(s) must have strong leadership abilities and demonstrated proficiency in managing large, multi-component programs. The NORC PD(s)/PI(s) must also be willing to participate in annual meetings of the NORC Program. 

Only institutions at which there is an ongoing, strong base of nutrition and/or obesity-related research are eligible. For new applications, at least 50% of the nutritional sciences and obesity or other related research comprising the research base must be supported with funds from Federal Agencies. In renewal applications, the NIH-supported research base may be less than 50% due, typically, to a growing number of investigators entering nutrition and/or obesity research from other fields. Each proposed core must be utilized by a minimum of two federally-funded investigators.

Application budgets are limited to $750,000 direct costs per year but need to reflect actual needs of the proposed Center. This budget limit is exclusive of F&A costs for consortium and subcontract arrangements. It is anticipated that the award budget will be directly correlated to the breadth, quality, and relevance to nutrition/obesity and related areas of the research base being served by the Center. Within the direct cost cap, up to $150,000 per year may be requested for the Pilot and Feasibility program.

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Only one application per institution is allowed. 

This Notice of Funding Opportunity (NOFO) invites applications from institutions/organizations that propose to establish a Research Resource Center (RRC) for the NIDDK Nutrition Obesity Research Centers (NORC) Program. The NORC Program consists of eleven Centers across the nation that support and enhance the national research effort in nutrition and obesity through cutting-edge basic, clinical, translational, and health disparities research in nutrition science and obesity. In collaboration with the existing NORC program, the RRC will (1) provide administrative support for the entire NORC Program, (2) establish and curate a NORC Program website and centralized repository of research resources, (3) implement a multi-pronged approach to support and grow a diverse early-to-midcareer research workforce with a goal of maximizing national outreach and impact, (4) administer and manage a NORC Opportunity Program to address gaps and promote collaboration, and (5) manage a Pilot and Feasibility Program.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Application budgets are limited to $625,000 Direct Costs in year one and $565,000 Direct Costs per year in years 2-5 exclusive of consortium F&As. 

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Summary

The purpose of this NOFO is to solicit proposals from highly qualified clinical sites in the US to join the Network through an X01 Resource Access Program award. Accepted sites will be designated as a Diagnostic Center of Excellence (DCoE) and will be responsible for generating participant clinical, phenotypic and sequencing data to be submitted to the DMCC through a Data Use Agreement with the Center. X01 recipients will have access to DMCC resources and infrastructure including access to high-quality phenotypic and genotypic data and collaboration with highly skilled physicians, researchers, and bioinformaticians. Using team science, DCoEs will be able to collaborate with Network members to implement strategies that will expand equity and access to health disparity populations and increase the discovery of new disease-associated genes and genomic variants, immunologic and metabolic abnormalities, as well as environmental insults that are causative in previously undiagnosed patients. DCoEs will be invited to submit their most challenging, unsolved cases for acceptance into the Network, and partner in their evaluation with the Network’s virtual case review committee(s), which will be coordinated by the DMCC.

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The National Institute for Occupational Safety and Health (NIOSH) within the Centers for Disease Control and Prevention (CDC) invites applications for the Centers for Agricultural Safety and Health (Ag Centers). These centers are expected to conduct high quality research and subsequently disseminate their findings and recommendations in audience appropriate products to contribute to improving the safety and health of agriculture, forestry, and fishing workers. Center structure should take advantage of diverse scientific resources and focus on local, regional, and/or national worker safety and health issues. Emphasis should be placed on the creation and implementation of evidence-based solutions that address important agricultural, forestry, and fishing safety and health problems. Centers should also use innovative approaches to identifying, understanding, and developing strategies for overcoming barriers to the adoption, adaptation, integration, scale-up and sustainability of evidence-based solutions. Collaborations with other academic institutions, nonprofit organizations, and other occupational safety and health focused groups are expected. Applicants must concisely describe the occupational safety and health burden within their service area and directly link research and outreach activities to help alleviate the burden. Applicants should also clearly articulate the anticipated impacts of the proposed work, both during the project period and beyond.

Ag Center Structure

NIOSH Ag Centers provide interdisciplinary research and outreach efforts to address AgFF-related occupational health and safety problems. Applicants should keep in mind the required and optional components essential to Ag Center function, detailed below, in providing an overall description of the proposed Ag Center, addressing 1) the burden of occupational injuries and illnesses within their region for this work sector, 2) the regional and national need for the Ag Center’s proposed programs and projects, and 3) the Center’s impact, or potential for impact, on AgFF worker health and safety.

The following required components enable Ag Centers to cohesively address their goals and objectives for providing impact:

Evaluation and Planning Core. The purpose of the Evaluation and Planning Core is to 1) provide oversight, leadership, and management for the Center, including establishment and maintenance of advisory committees; 2) engage in long-range planning, coordination, and implementation of work that crosses multiple cores, programs or projects; and 3) develop and assist in implementing evaluation efforts at the Center, core, program and project levels. Any collaborative projects with other Ag Centers should include the Evaluation and Planning Core for the purposes of oversight and coordination.

Outreach Core. The purpose of the Outreach Core is to ensure that evidence-based approaches, technologies, guidelines, policies, best practices, or similar activities are promoted and implemented in affected populations to benefit workers and their associated work environments. Much of the work in the Outreach Core will be implemented through partnerships and collaborations with nonprofit organizations, community groups, industry groups, employers, or similar entities.

Research Core. The purpose of the Research Core is to develop programs and projects in response to the goals identified in the Center's strategic plan and subsequently manage, monitor, and coordinate this work within the Center. Research activities include basic/etiologic, intervention, translation, and surveillance. Activities can vary widely, from pilot or feasibility studies that are minimally resourced and may be exploratory in nature to large, R01-like projects that require preliminary data and significant investment in personnel, equipment, time, and space. The Research Core is comprised of the required research projects and the optional Pilot/Feasibility Program Please note, the "Research Core" is not an actual component within the application - instead it is a construct to address budget limits across multiple and varied activities (i.e., required research projects and the optional pilot/feasibility program). There is no limitation to the number of research projects that applicants can propose as long as they stay within the annual direct costs requirements.

Objectives/Outcomes

The primary goal of an Ag Center is to conduct high quality scientific research and outreach efforts to address local, regional, and national AgFF problems. This will ultimately be accomplished through the goals in the Center’s Strategic Plan. However, the operational process for accomplishing these goals should not be overlooked and therefore, each core, program and project should develop operational objectives to support the goals in the Plan.

Target Population

There are many affected subpopulations in AgFF professions. The attributes of these affected subpopulations (such as demographics, size, risks/hazards encountered, and resources available to educate or assist in addressing the problem) will drive the proposed projects and their anticipated outputs and impacts. Ag Centers are distributed throughout the nation to be responsive to safety and health issues unique to different regions of the country. The risks inherent to an AgFF job are often dependent on the work environment, local/industry work practices, and specific job tasks. Therefore, Ag Centers should clearly describe the specific target populations they are focusing their efforts on and provide information to support the need for these proposed efforts.

Industry Sectors, Health and Safety Cross-sectors, and Goals

In the Project Description/Abstract of the application, state which industry sector(s) and health and safety cross-sector(s) the proposed work will address. Provide a clear rationale for how the intended outcomes of the proposed project will contribute to the specified goals in NIOSH's Strategic Plan and, in particular, those identified in the NIOSH Priority Goals for Extramural Research.

Diversity, Equity and Inclusion

In June 2019, NIOSH began an initiative to take substantive action in creating greater diversity, equity, and inclusion in its workforce, the workplace and in its service to the public. This initiative led to the establishment of the NIOSH Diversity and Inclusion Office. The associated strategic plan is intended to guide actions that specifically address diversity, equity and inclusion (DEI) in all aspects of NIOSH's work, including NIOSH-supported extramural programs. Ag Centers should demonstrate a commitment to DEI in all aspects of their center. This commitment should be reflected in the center's core values, mission and outputs.

Asymmetrical power relationships along social axes such as age, class, gender, nativity, and race/ethnicity not only result in social, economic, and environmental disadvantages that impact the distribution of work-related benefits and risks but also result in exclusionary research practices. Developing inclusive research practices, and the institutional capacity to effectively produce data driven solutions that reduce these avoidable inequities, is essential to ensuring the well-being of the increasingly diverse AgFF workforce.

Applicants should describe how they propose to ensure inclusive governance and practice in the required center components (Evaluation and Planning, Outreach, and Research). Discussion should include, but not be limited to, how historically underrepresented groups will be included in agenda setting for the work of the center. For example, this may include participation on advisory boards, as researchers/staff and through partnerships. Applicants should also identify how the center will ensure that research questions, data collection methods and analysis, and dissemination of results will be inclusive of the diversity in the AgFF workforce, especially those from historically underrepresented groups. Applicants should demonstrate how the design, content, format, and dissemination of outreach efforts will be tailored to the needs of workers from diverse backgrounds.

Collaboration/Partnerships

Ag Centers must demonstrate collaborative efforts by working with a diverse and broad range of organizations to enhance worker safety and health in their region. Possible collaborators include universities, labor and professional associations, nonprofit organizations, businesses, and federal, state, or local public health and regulatory agencies. Centers should seek to address a wide range of occupational safety and health concerns in their region, as determined by the burdens posed by these problems or hazards, and their funding applications must describe how their efforts will alleviate or eliminate these burdens.

Evaluation/Performance Measurement

All Center activities should be managed and coordinated as part of the Evaluation and Planning Core. This core is responsible for all new and ongoing center-wide evaluation activities as well as supporting program and project level evaluation efforts. These activities should all be described in a Center evaluation plan. Ag Centers are also strongly encouraged to interact with each other on evaluation methods and best practices, to increase awareness of activities and evaluation techniques. Similarly, centers will work with each other and NIOSH during the performance period to develop shared logic models on common AgFF health and safety outcomes. In addition to center-specific evaluation and performance measurement, Ag Centers may be asked to participate in NIOSH evaluation efforts related to the NIOSH AgFF Program and the NIOSH Evaluation Capacity Building Plan.

Translation Plan

The transfer of evidence-based approaches to intermediaries such as unions, manufacturers, worker groups and end users (employers and workers) through training, conferences, community gatherings, social media, blogs, websites and infographics, peer-reviewed and lay publications, etc. is an essential function of the Outreach Core. While research strengthens our understanding of the determinants of injury, illness, and death, the potential for impact of research findings is found when paired with pragmatic approaches to move findings into practice.

1. Evaluation and Planning Core
2. Outreach Core
3. Research Projects (collectively, the "Research Core", along with the optional Pilot/Feasibility Program)

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The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P&F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in diverse perspectives, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. 

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The four-year RHRC Program awards will support research centers with specific rural health research areas of concentration. The topic(s) of concentration must relate to policy issues intended to inform the improvement of health care in rural areas. The topic(s) of concentration must also be of enduring interest and importance to rural providers, rural stakeholders, policymakers, and/or rural communities. RHRC recipients will conduct policy-oriented health services research. In addition to primary and secondary research, the applicant may conduct literature syntheses and update existing research to produce timely and relevant information. 

You may apply for either the:

(1) RHRC Program (base award of up to $700,000 per year for 4 years) alone; or
(2) RHRC Program (base award of up to $700,000 per year for 4 years) and Optional RHRC Supplement (of up to $250,000) awarded no more than once per year for each year of the 4-year period of performance.

Limit: 1 //  J. Burgess (Community, Environment & Policy)

Your organization may submit only one application under this announcement.

The purpose of the NOFO is to establish and maintain a network of Regional Centers for Public Health Preparedness and Response to increase implementation of evidence-based strategies and interventions (EBSIs) and to improve public health preparedness and response, as informed by the needs of the communities involved. Support will be provided for up to ten centers to determine and support implementation of activities needed to increase use of EBSIs that will improve public health preparedness and response, as informed by the needs of the communities as described in regional workplans. The goal is to fund one center in each of the 10 HHS Regions. Each center will1) Coordinate relevant activities with applicable State, local, and Tribal health departments and officials, health care facilities, and health care coalitions to improve public health preparedness and response, as informed by the needs of the community, or communities involved.2) Develop and implement activities to support focus areas and objectives created by a regional coordinating body in 2023-24.3) As determined necessary by the CDC, and based on the availability of funding, support further implementation of evidence-based practices, or conduct research, evaluation, translation or dissemination necessary to address active or anticipated public health emergencies.4) One center will be awarded additional funds to support coordination and convening of centers and provide technical assistance and training as needed.