Center

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Only one application per institution is allowed. Applicants can only apply for funding under one funding opportunity number, either HRSA-24-042 (DPs) or HRSA-24-041 (NCCT). Applicants applying for the HRSA-24-042 (DPs) may only apply for one focus area, autism or epilepsy, and must clearly state the focus area for which they are applying. HRSA will not consider funding applicants who apply to more than one funding opportunity number or focus area.

This notice announces the opportunity to apply for funding under the Transition3 for Youth with Autism and/or Epilepsy program, which includes the Transition for Youth with Autism and/or Epilepsy Demonstration Projects (DPs) (HRSA-24-042) and the National Coordinating Center on Transition (NCCT) (HRSA-24-041). The purpose of this program is to develop and advance national, state, and local/community-level frameworks that support successful transition from child to adult serving systems4 for youth with autism and/or epilepsy who have complex health and social needs and require a higher level of family support and coordination (YAES).5 This announcement includes instructions for applying to two separate awards. You may only apply for HRSA-24-042 (DPs) or HRSA-24-041 (NCCT), but not both projects. HRSA will not consider funding applicants who apply to more than one funding opportunity number or focus areas.

The goal of this program is to improve outcomes including quality of life and well-being for YAES and their families/caregivers transitioning from child to adult systems. These systems include but are not limited to post-secondary education, inclusive post-secondary education, employment, community, independent/daily living, and healthcare.6 The target population for this program is characterized as YAES between the ages of 13 and 26 who have co-occurring conditions, intellectual disabilities, experience challenges in social cognition, communication, interpersonal skills, and/or behaviors7 8 9 and require a higher level of family support and coordination.

HRSA-24-041 (NCCT): One NCCT will be funded to support the HRSA-24-042 (DP) recipients in meeting their program objectives, and to provide national leadership to improve transition outcomes for YAES and their families/caregivers through training, technical assistance, evaluation, and the development and dissemination of resources to transition stakeholders,11 including Title V programs.

Applicants can only apply for funding under one funding opportunity number, either HRSA-24-042 (DPs) or HRSA-24-041 (NCCT). Applicants applying for the HRSA-24-042 (DPs) may only apply for one focus area, autism or epilepsy, and must clearly state the focus area for which they are applying.7 HRSA will not consider funding applicants who apply to more than one funding opportunity number or focus area.

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UArizona may submit one pre-application.

AHA Membership Requirement: Any individual applying as a Center Director or a Project Principal Investigator (PI) must be an AHA Professional Member before submitting a full proposal. (Membership is not required to submit a pre-proposal.) Join or renew when preparing an application in ProposalCentral, online, or by phone at 301-223-2307 or 800-787-8984. Membership processing may take 3-5 days; do not wait until the application deadline to renew or join.

Required Pre-Proposal 

Each Center Director is required to send a pre-proposal USE THIS LINK to provide the following:

• Name and institution of the Center Director and each Project PI
• Center title, and title and performance site of each proposed project

If required, the mechanism through which partnering requirements are being met. See “Additional Expectations and Opportunities” and “Institutional Eligibility/Location of Work” sections.

As part of the required Pre-Proposal, if the submitting institution or a partnering institution is not a research-intensive institution of higher learning, the lead for that institution must upload a letter from a Senior Institutional Official (e.g., president, provost, dean, etc.) indicating they meet the definition of a non-research-intensive institution as stated in the “Additional Expectations and Opportunities” section. 

AHA staff will review for compliance. A non-complying institution will not be permitted to submit a full proposal. This administrative review is part of the Pre-Proposal process, which is required and, though rare, may prevent an applicant from moving forward. Even though the Pre-Proposal is required, each Center and Project applicants should begin planning and designing their applications before the Pre-Proposal deadline to maximize the amount of time available to develop their full proposal.

Purpose
The American Heart Association (AHA) announces this Request for Proposals for the Strategically Focused Research Network (SFRN) on Inflammation in Cardiac and Neurovascular Disease.

THE ROLE OF INFLAMMATION IN CARDIAC AND NEUROVASCULAR DISEASE

Throughout the body, inflammation plays a crucial role in maintaining tissue homeostasis and initiating appropriate immune responses against pathogens or injury. However, dysregulation of inflammatory processes can lead to detrimental effects, contributing to the development and progression of many disease states, such as autoimmune conditions, cancer, diabetes, kidney disease and liver disease.1

The heart and nervous system are also subject to disease with dysregulation of the inflammatory system. Inflammatory myocarditis, characterized by inflammation of the myocardium, is more likely to occur in males compared to females.2 It is most commonly triggered by viral infection; triggering viruses include adenoviruses, enteroviruses, parvoviruses and coronaviruses (including SARS-CoV-2), among others.3  Less commonly, myocarditis is caused by bacterial or fungal infection or autoimmune diseases.  Of more recent note, it was discovered during the COVID-19 pandemic that vaccines developed against SARS-CoV-2, particularly those using mRNA technology, elicited myocarditis in a subset of vaccine recipients.4 The highest incidence (approximately 50 / 100,000) was found in men under 40. 

Myocarditis can be subclassified based on a number of characteristics. The most prominent symptoms are chest pain and dyspnea,5 and in many cases, myocarditis may resolve on its own. One notable exception is fulminant myocarditis, a rare and severe form of myocarditis that is responsible for a high proportion of cardiac-related deaths in young individuals.6 Acute myocarditis is defined as that for which symptoms are of recent onset, generally within a month or so. Inflammatory processes associated with myocarditis, such as infiltration of immune cells, release of pro-inflammatory cytokines, and oxidative stress, can lead to myocyte damage, fibrosis, and impaired contractility.3,7-8 Myocarditis that is associated with cardiac dysfunction and remodeling of the ventricle is referred to as inflammatory cardiomyopathy, a condition that is typically irreversible. It may result in arrhythmias, ventricular dysfunction or heart failure and requires lifelong therapy and/or heart transplant.

Within the nervous system, inflammation has been implicated in an array of pathologies, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.9-10 Inflammation also plays a prominent role in stroke.11-13  A robust neuroinflammatory response is initiated following an ischemic event. Sex differences are also observed with stroke, with the risk being higher for females than males.14 The primary cause of this neuroinflammation is the activation of immune cells in the brain, including microglia and astrocytes. These cells are responsible for defending the brain against pathogens and injuries. However, under certain conditions, they can become overactivated and release inflammatory molecules. Neuroinflammation can have both beneficial and detrimental effects. In acute situations, neuroinflammation helps clear pathogens, promote tissue repair, and support the restoration of normal brain function. However, chronic or excessive neuroinflammation can damage neurons, impair synaptic communication, break down the blood-brain barrier, and disrupt the delicate balance of the brain's environment.11

CARDIOTOXICITY 
Cardiotoxicity describes a condition wherein a decrease in cardiac function results from administration of drugs or other agents. Currently, the term is largely identified with changes in cardiovascular function resulting from treatment with a number of cancer therapies. Whereas a decrease in left ventricular ejection fraction is the cardiac parameter most closely aligned with cardiotoxicity, additional cardiac effects (e.g., left ventricular systolic dysfunction, angina, and acute coronary syndrome) may also be characterized as cardiotoxicity.15 

There are several potential mechanisms underlying cardiotoxicity of chemotherapeutic agents, including inflammation. For example, use of chemotherapeutics of the anthracycline class, widely prescribed because of their efficacy against both solid and hematologic tumors, is associated with a high incidence of cardiotoxicity.16 Despite this effect of anthracyclines being described decades ago, the mechanism(s) underlying cardiotoxicity are not fully elucidated. Studies in more recent years do suggest, however, that at least part of the cardiotoxic actions of anthracyclines are related to inflammation.17 In addition, pre-clinical studies assessing effects of anti-inflammatory agents against anthracycline-induced cardiotoxicity have shown favorable results.18-19  Targeting inflammation thus holds promise for preventing or mitigating cardiotoxic effects of this class of chemotherapeutic. 

More contemporary cancer treatments also elicit adverse cardiac effects. Immune checkpoint inhibitors (ICIs), a new and promising class of anti-cancer drugs, may elicit a severe form of myocarditis.20 Whereas the incidence is relatively low, the mortality rate is high, due in part to the fact that many individuals present with a fulminant-like form of myocarditis. The mechanism underlying ICI-induced myocarditis remains unclear. The promise of this new class of cancer treatment will not be fully realized unless the mechanism is identified, which will facilitate therapeutic strategies to prevent or mitigate this severe adverse effect.   

While our understanding of the role inflammation plays in cardiac and brain dysfunction has grown considerably in recent years, several hindrances remain that preclude improved recognition and treatment of these conditions. For instance, significant gaps remain in understanding of the downstream signaling events and potential crosstalk; development of new animal and in vitro models would support these needs. In addition, notable opportunities for optimization of diagnostic capabilities exist, such as identification and assessment of biomarkers with improved specificity and development of improved imaging techniques. Clinical trials designed to assess outcomes more specifically for distinct types and/or stages of inflammatory conditions are also needed. 

Limit: 1 // PI: C. Laskowski (College of Law)
 

The Humanities Research Centers on Artificial Intelligence program aims to support a more holistic understanding of artificial intelligence (AI) in the modern world through the creation of new humanities research centers on artificial intelligence at eligible institutions. Centers must focus their scholarly activities on exploring the ethical, legal, or societal implications of AI.  

A Center is a sustained collaboration among scholars focused on exploring a specific topic. Successful applicants will examine the humanities implications of AI through two or more related scholarly activities. Centers must be led by scholars in the humanities or humanistic social sciences, but should include scholars from multiple disciplines. Scholars may come from one or more institutions. NEH welcomes international collaboration, but scholars at U.S. institutions must contribute significantly to the project. This program is for establishing new Centers; existing Centers and Institutes are not eligible in this competition.

In addition to the establishment of a sustainable Center, your project should engage in at least two activities that support research into the ethical, legal, or societal implications of AI. Appropriate activities may include but are not limited to: collaborative research and writing efforts; workshops or lecture series; education and mentoring; and the creation of digital tools to increase or advance scholarly discourse about AI.  

Institutionally coordinated // Limit 1 // PI: J. M. Wang-Roveda (Electrical and Computer Engineering)
 

Institutionally coordinated submission. Contact RDS for more information.
Number of pre-proporsals allowed as lead institution: two

Artificial Intelligence (AI) has advanced tremendously and today promises personalized healthcare; enhanced national security; improved transportation; and more effective education, to name just a few benefits. Increased computing power, the availability of large datasets and streaming data, and algorithmic advances in machine learning (ML) have made it possible for AI research and development to create new sectors of the economy and revitalize industries. Continued advancement, enabled by sustained federal investment and channeled toward issues of national importance, holds the potential for further economic impact and quality-of-life improvements.

The 2023 update to the National Artificial Intelligence Research and Development Strategic Plan, informed by visioning activities in the scientific community as well as interaction with the public, identifies as its first strategic objective the need to make long-term investments in AI research in areas with the potential for long-term payoffs in AI. AI Institutes represent a cornerstone Federal Government commitment to fostering long-term, fundamental research in AI while also delivering significantly on each of the other eight objectives in that strategy. The National Security Commission on Artificial Intelligence (NSCAI) identifies AI Institutes as a key component of a bold, sustained federal push to scale and coordinate federal AI R&D funding and to reinforce the foundation of technical leadership in AI.

This program is a multisector effort led by the National Science Foundation (NSF), in partnership with the Simons Foundation (SF), the National Institute of Standards and Technology (NIST), Department of Defense (DOD) Office of the Under Secretary of Defense for Research and Engineering (OUSD (R&E)), Capital One Financial Corporation (Capital One), and Intel Corporation (Intel).

This program solicitation expands the nationwide network of AI Research Institutes with new funding opportunities over the next two years. In this round, the program invites proposals for institutes that have a principal focus in one of the following themes aimed at transformational advances in a range of economic sectors, and science and engineering fields:

• Group 1 - Awards anticipated in FY 2024:
  • Theme 1: AI for Astronomical Sciences
     
• Group 2 - Awards anticipated in FY 2025:
  • Theme 2: AI for Discovery in Materials Research
  • Theme 3: Strengthening AI

No applicants  // Limit: 1 // Tickets Available: 1 

An organization may only submit 1 proposal as the lead. There is no limit on the number of proposals on which an organization can be included as a sub-recipient.

The National Science Foundation (NSF) is soliciting proposals for managing the operation and maintenance of the National Geophysical Facility (hereafter referred to as NGF) an NSF-funded major facility. The NGF is designed to enable the research community to ask, and address, questions about a variety of Earth processes from local to global scales. NGF will operate global and regional networks of sensors; provide a lending library of instrumentation and support services to enable PI-led field experiments; support archiving, quality control, and delivery of geophysical data and data product development; and provide education, outreach, workforce development, and community engagement activities that serve a wide range of audiences. NGF will be a single facility, with a single operator that will succeed NSF’s current geophysical facilities, the Seismological Facility for the Advancement of GEoscience (SAGE) and the Geodetic Facility for the Advancement of GEoscience (GAGE).

The award recipient will work closely with NSF and the scientific community to ensure that NGF capabilities support, and advance, Earth Sciences and related disciplines. In cooperation with NSF, and within available resources, the recipient will plan and execute a viable, coherent, and inclusive program to: (1) streamline the management and operations of existing geophysical facility capabilities into one consolidated geophysical facility; (2) enhance existing facility capabilities in instrumentation, data services and cyberinfrastructure; and (3) implement a bold vision to broaden participation and foster a culture of equity and inclusion in the Earth Sciences and related disciplines.

The NSF Division of Earth Sciences (EAR) in the Directorate for Geosciences (GEO) has primary responsibility for the programmatic oversight of NGF and activities will be coordinated with the Division of Ocean Sciences (OCE), Division of Atmospheric and Geospace Sciences (AGS), and Office of Polar Programs (OPP). 

A single award will be made as a cooperative agreement with a duration of five years. NSF may renew the award for an additional five years, subject to availability of funds, the recipient's satisfactory performance, and review of a cost proposal for the second 5-year period. NSF’s decision will be informed by the National Science Board Statement on Recompetition of Major Facilities (NSB 2015-45 or its successor).
 

For planning purposes, proposers can assume a base budget of approximately $39.5 million during the first year of the award, beginning October 2025 and should plan for no more than a 6% budget increase in each of the subsequent years. All budget amounts given herein are tentative and for initial planning purposes only. Actual annual funding increments will be determined based on the detailed cost estimate required per Section VII.C below and an Annual Plan and Budget submitted by the recipient to, and approved by, NSF. Funding increments are subject annually to the availability of funds and will be contingent on the performance of the recipient. Ongoing recapitalization of instrumentation, and escalation factors used for cost estimating, should be articulated in the Cost Estimating Plan.

Transition funding of up to $1,000,000 for a duration of up to six (6) months will be available for organizations other than the incumbent organization. Relevant transition activities include interviewing and hiring personnel, establishing subcontracts, transferring data and property, and obtaining permits and licenses. Should a transition period be necessary, the incumbent will retain responsibility for management of NGF and the new recipient will have the appropriate level of access to incumbent personnel and facilities associated with NGF as determined by NSF. The funding request for a transition period should be made within the Transition Plan and should not be included in the formal cost estimate or proposed budget for the initial 5-year period but must conform to the same requirements.

No applicants // Limit: 1 // Tickets Available: 1 


Only one application per institution is allowed.

The NEI Center Core Grant combines three or more Resource and/or Service Cores for a group of R01 investigators to enhance their research, consolidate resources, avoid duplication of efforts, and/or contribute to cost effectiveness by providing a service with lower costs or higher quality than could be attempted for independent projects by several individual Program Directors/Principal Investigators (PD(s)/PI(s)). Shared resources and facilities that are accessible to a group of independently funded investigators lead to greater productivity for the separate projects and can provide instrumentation and facilities that are too costly to be maintained by an individual investigator. The design and purpose of each Center Core may vary in how it serves its users. This program is designed to enhance an institution's environment and capability to conduct vision research and to facilitate collaborative studies of the visual system and its disorders and promote new research within the NEI mission and Strategic Plan. 

No applicants // Limit: 1 // Tickets Available: 1 

Only one application per institution is allowed.

NIOSH is seeking applications from qualified organizations for a National Center for Construction Safety and Health Research and Translation (also known as the NIOSH National Construction Center). Applicants areexpected to propose multi-disciplinary approaches for impactful applied and intervention research and hazard identification and controls, to develop partnerships for implementing prevention and intervention activities, and to serve as leaders in research translation and research-to-practice for the protection of construction workers in the United States. The NIOSH National Construction Center will accomplish these goals by 1) integrating and advancing research, 2) translating and disseminating best practices, 3) disseminating information, 4) informing policy, and 5) building capacity. Applicants must describe the occupational health and safety burden(s) addressed in their proposals. In addition, they must link the need for the proposed research and related activities to the planned outputs and outcomes that will help address or alleviate the construction sector burdens described. Applicants should also describe the anticipated impacts and potential outcomes of the proposed research and related activities that will occur during the 5-year project period and beyond.

Limit: 1  // PI: M. Chertkov (Mathematics)

Uarizona may submit one proposal.

Despite decades of research, scientists do not fully understand the dynamic nature of pathogen and disease emergence. Emerging (and re-emerging) pathogens represent a continuing risk to national security because they threaten health (animal, human, and ecosystem) and economic stability. Often, society falls short on the coordination and breadth of expertise needed to respond to such threats. Effective responses to emerging pathogens will require sustained, global-scale efforts of researchers and organizations. This can only be accomplished by synergistic integration of innovative scientific and technological advances across disciplines and scales, and effective knowledge transfer into practice. As part of these efforts, NSF is organizing a set of activities around the broad theme of Predictive Intelligence for Pandemic Prevention (PIPP).

The PIPP initiative focuses on foundational research and development activities needed to tackle grand challenges in infectious disease pandemics through prediction and prevention. The PIPP Phase II Centers Program expands upon the Phase I Development Grant Program and is the NSF's flagship program to establish a network of Centers or large-scale awards/investments that will support interdisciplinary team-based approaches to accelerate research and development activities in emerging infectious diseases and pandemics. The overall goal of the PIPP Phase II Centers program is to support research and development activities needed to transform society's ability to forecast the likelihood of pandemic-scale events, detect outbreaks early, and respond efficiently.

Continued advancement, enabled by sustained federal investment channeled toward issues of national importance holds the potential for further economic impact and public health improvements.

Informed by visioning activities in the scientific community as well as a previous round of development grant activities (PIPP Phase I), the program invites proposals for Centers that have a principal focus in one of the following multidisciplinary themes:

Theme 1: Pre-emergence - Predicting and detecting rare events in complex, dynamical systems

Theme 2: Data, AI/ML and Design - Computing, manufacturing and technology innovation for pandemics

Theme 3: The Host as the Universe - Identifying host-pathogen tipping points that dictate control or spread of an infection

Theme 4: Human Systems - The role of human behavior, activities and environments in disease emergence, transmission, and response or mitigation

These components directly support the NSF's strategic goals by funding cutting edge science aimed at societal challenges and opportunities that face the Nation, while concurrently working to develop a globally competitive and diverse science, engineering and technology-adept workforce.

The Directorates for Biological Sciences (BIO), Computer Information Science and Engineering (CISE), Engineering (ENG), Social, Behavioral and Economic Sciences (SBE), and Mathematics and Physical Sciences (MPS) are jointly collaborating to support the PIPP Phase II activities. Involvement of and collaboration with other research communities with significant effort in related spaces, including use-inspired research is highly encouraged.

Institutionally coordinated  // Limit: 2 // PI: A. Zabludoff (Astronomy)

Institutionally coordinated submission. Contact RDS for more information.
Number of pre-proporsals allowed as lead institution: two

Artificial Intelligence (AI) has advanced tremendously and today promises personalized healthcare; enhanced national security; improved transportation; and more effective education, to name just a few benefits. Increased computing power, the availability of large datasets and streaming data, and algorithmic advances in machine learning (ML) have made it possible for AI research and development to create new sectors of the economy and revitalize industries. Continued advancement, enabled by sustained federal investment and channeled toward issues of national importance, holds the potential for further economic impact and quality-of-life improvements.

The 2023 update to the National Artificial Intelligence Research and Development Strategic Plan, informed by visioning activities in the scientific community as well as interaction with the public, identifies as its first strategic objective the need to make long-term investments in AI research in areas with the potential for long-term payoffs in AI. AI Institutes represent a cornerstone Federal Government commitment to fostering long-term, fundamental research in AI while also delivering significantly on each of the other eight objectives in that strategy. The National Security Commission on Artificial Intelligence (NSCAI) identifies AI Institutes as a key component of a bold, sustained federal push to scale and coordinate federal AI R&D funding and to reinforce the foundation of technical leadership in AI.

This program is a multisector effort led by the National Science Foundation (NSF), in partnership with the Simons Foundation (SF), the National Institute of Standards and Technology (NIST), Department of Defense (DOD) Office of the Under Secretary of Defense for Research and Engineering (OUSD (R&E)), Capital One Financial Corporation (Capital One), and Intel Corporation (Intel).

This program solicitation expands the nationwide network of AI Research Institutes with new funding opportunities over the next two years. In this round, the program invites proposals for institutes that have a principal focus in one of the following themes aimed at transformational advances in a range of economic sectors, and science and engineering fields:

• Group 1 - Awards anticipated in FY 2024:
  • Theme 1: AI for Astronomical Sciences
     
• Group 2 - Awards anticipated in FY 2025:
  • Theme 2: AI for Discovery in Materials Research
  • Theme 3: Strengthening AI

No applicants // Limit: 1 // Tickets Available: 1 

UArizona may submit one proposal to this funding program. 

The purpose of this RFP is to further advance NIMHD’s mission by supporting Centers of Excellence to enhance research training and education of academic faculty (including post-doctoral fellows, junior faculty, and other early-stage investigators) in the conduct of minority health and health disparities research.
 

NIMHD focuses on the full continuum of causes of health disparities and the interventions to address these causes. Projects must include a focus on one or more of the following NIH-designated populations that experience health disparities in the United States. The Center of Excellence must include the following required components:

• Overall
• Administrative Core
• Investigator Development Core
• Community Engagement and Dissemination Core