National Institutes of Health (NIH)

NIAID and NIDDK Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to encourage researchers from diverse backgrounds to work with their institutions to submit applications for research projects within the mission of either NIAID or NIDDK. This NOFO seeks to support either (a) a New Investigator (NI), who has not previously competed successfully for substantial, independent funding from NIH, or (b) an 'At-Risk' investigator, who had prior support as a PD/PI on a substantial independent research award and unless successful in securing a substantial research grant award in the current fiscal year, will have no substantial research grant funding in the following fiscal year.

Eligible candidates will identify with one of the two categories below:

1. New Investigator (NI)

For the purpose of this NOFO, an investigator is considered a New Investigator (NI; https://grants.nih.gov/policy/early-investigators/index.htm) if they have not competed successfully for substantial, NIH independent funding from NIH. A "substantial" research award is a research grant award excluding smaller grants that maintain Early Stage Investigator (ESI)/NI status (see full list of awards here: https://grants.nih.gov/policy/early-investigators/list-smaller-grants.htm). PD/PIs of NIH Training-Related and Mentored Career Awards are still considered New Investigators if the NIH awards are in any of the following categories: fellowships (F awards), individual or institutional career awards (K awards), and loan repayment contracts (L30, L32, L40, L50, L60). Appointees who have received support from any NIH training grants (T32, T34, T35, T90, D43) are also considered New Investigators.

OR

2. At-Risk Investigator

For the purpose of this NOFO, an investigator is considered an At-Risk Investigator if they have had prior support as a Principal Investigator on a substantial independent research award and, unless successful in securing a substantial research grant award in the current fiscal year, will have no substantial research grant funding in the following fiscal year. A "substantial" research award is a research grant award excluding smaller grants that maintain ESI/NI status

Opportunity ID
a129d9dd-dacf-45b6-8c19-f2f1552f7976
External Deadline
02/05/2024

Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)

The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project that represents a change in research direction for an early stage investigator (ESI) and for which no preliminary data exist. Applications submitted to this Funding Opportunity Announcement (FOA) must not include preliminary data. Applications must include a separate attachment describing the change in research direction.

The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
This Funding Opportunity Announcement does not accept applications proposing clinical trials.
Opportunity ID
958f40d9-3f44-4b36-bad2-d1d75de8f0f3
External Deadline
12/23/2023

Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to provide support for new investigators from diverse backgrounds, including from groups nationally underrepresented in biomedical, clinical, behavioral and social sciences research, to conduct small research projects in the scientific mission areas of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or the National Human Genome Research Institute (NHGRI). New investigators at the time of award under this FOA will have had less than $125,000 direct costs of combined research funding (excluding NIH training and NIH career awards). This R21 will support small research projects that can be carried out in a short period of time with limited resources and seeks to facilitate transition to research independence. The R21 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

Components of Participating Organizations:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Human Genome Research Institute (NHGRI)
Opportunity ID
f9a649d9-5afb-4ed7-8a8e-d1d75de8f0f3
External Deadline
02/16/2024

NIH PAR-23-221: 2024 NIH Advancing Research Careers (ARC) Institutionally-Focused Research Education Award to Promote Diversity (UE5 - Clinical Trial Not Allowed)

No applicants   // Limit: 1 // Tickets Available: 1 

 

NIH Research Education Program supports research education activities in the mission areas of the NIH. The overarching goal of this ARC UE5 program is to support educational activities that encourage individuals from diverse backgrounds, for example those from groups underrepresented in the biomedical and behavioral sciences (see Notice of NIH's Interest in Diversity ), to pursue further studies or careers in research. The overarching goal of this UE5 program is to support educational activities that encourage individuals from diverse backgrounds, for example those from groups underrepresented in the biomedical and behavioral sciences (see Notice of NIH’s Interest in Diversity), to pursue further studies or careers in research.

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on:

  • Courses for Skills Development
  • Mentoring Activities

Applications are encouraged from organizations that have:

  • Experience enhancing scientific communication and networking among early-career biomedical researchers;
  • An established record of providing professional development and networking activities for future biomedical researchers; and
  • A demonstrated commitment to enhancing the diversity of the biomedical research workforce.

The program provides support for well-designed courses for skills development and mentoring activities to prepare cohorts of ARC predoctoral F99 fellows and K00 postdoctoral scholars to transition into and succeed in mentored postdoctoral research, positioning them to advance in impactful careers in the biomedical research workforce that typically require postdoctoral training (e.g., academic research and teaching at a range of institution types, industry or government research).
Recipient organizations must provide career development and mentoring activities aligned with and appropriate for the disciplinary backgrounds and career goals of scholars supported through the ARC F99/K00 program.

Components of Participating Organizations:
National Institute of General Medical Sciences (NIGMS)
National Center for Complementary and Integrative Health (NCCIH)
Sexual and Gender Minority Research Office (SGMRO)

Internal Deadline
External Deadline
01/29/2024

NIH RFA-AG-24-013: 2023 NIA Expanding Research in AD/ADRD (ERA) Summer Research Education Program (R25 - Independent Clinical Trial Not Allowed)

Limit: 2* // Tickets Available: 1 // M. H.Witte (Surgery, Neurosurgery, and Pediatrics) 

*No more than two applications are allowed per institution. If two applications are submitted then the 2 awards must be for different target groups.
 

A major goal of the National Plan to address Alzheimer’s Disease (AD) and Alzheimer’s Disease-related Dementias (ADRD)  is to reduce the burden of AD/ADRD by accelerating research toward treatments, improving care and support for people facing these conditions now, and reducing the risk of AD/ADRD by promoting brain health. Despite this, there is a shortage of scientists conducting the wide variety of necessary innovative and interdisciplinary research projects, including basic biomedical, clinical, translational, prevention, and treatment research on AD/ADRD. This Funding Opportunity Announcement (FOA) aims to address goal G-4 of the National Institute on Aging's Strategic Directions for Research (2020-2025): “Attract and train more researchers from diverse scientific and cultural backgrounds." This will include supporting the recruitment of early-stage investigators from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to the NIH AD/ADRD portfolio. This FOA also aims to address the lack of early exposure to high-quality, hands-on research education experiences in the AD/ADRD field, another major barrier to increasing the AD/ADRD capable workforce.

To further expand the AD/ADRD training pipeline for earlier stage students, NIA will support summer research experiences for high school students, undergraduates, or science teachers. The expectation is that such a program would incubate and develop the next generation of  early-stage investigators to pursue research careers representative of in NIA mission critical areas, namely AD/ADRD research. Proposed programs should provide authentic "open-ended", hands-on exposure to AD/ADRD research as it relates to aging as part of a comprehensive program based in sound educational practices designed to stimulate the interest and advance the knowledge base of participants. In addition to hands-on research experiences, programs are expected to include complementary educational enrichment activities that support the participants' scientific development, such as relevant workshops (e.g., scientific writing and presentation skills), journal clubs, technical laboratory coursework, and training in rigor and reproducibility. Program goals and objectives should be grounded in literature and appropriate for the educational level of the audience to be reached, including the content to be conveyed, and the intended outcome(s). Outcomes for high school students may include preparing them for undergraduate admissions and enhancing their interest in pursuing a science decree. Outcomes for college students may include: reinforcing their intent to graduate with a science degree, preparing them for graduate or medical school admissions, and/or preparing them for careers in AD/ADRD research. Support for science teachers will be limited to those programs with a clear plan for how teachers will utilize their summer experience in their teaching during the school year, such as enhancing the STEM curriculum or increasing number of STEM courses taught. 

Focus on High School Students, Undergraduates, or Science Teachers: Science education research has demonstrated that early exposure to scientific research leads to the retention of trainees in science, technology, engineering, and mathematics (STEM). The President’s Council of Advisors on Science and Technology (PCAST) specifically highlights the need for retention of trainees in STEM by involving them in contemporary, hands-on research experiences especially during the first two years of college. Summer research experiences provide important experiential learning to sustain students’ interests in STEM and medicine careers. The short-term summer experience, in contrast to a year-long experience, allows for a focused and concentrated effort on instruction, and intentionally coincides with the time of year when the target populations of this program (i.e., high school students, undergraduate college students, and science teachers) would typically have the opportunity to engage in such a research educational experience. 

For the purpose of this announcement, institutions should explain how this program will be developed in a way that will foster diversity and inclusion at their organization. As indicated below, applicants must include a Recruitment Plan to Enhance Diversity which describes the program’s proposed recruitment efforts and how the proposed plan reflects past experiences in recruiting individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences (see NOT-OD-20-031 for additional information on NIH's Notice of Interest in Diversity). All programs are expected to be inclusive, supportive, and safe, and to provide opportunities for participants to interact with investigators who could contribute to their growth. Applications from a variety of institutions, including those from minority serving institutions (MSIs), are  encouraged.

Applicants should consider how the developed programs can optimize participation and potentially include additional participants from outside the applicant institution, especially those in local and/or affiliated institutions. Applicants must demonstrate how this program will add significant value over existing programs at the applicant institution.

Each institution must have a unique program structure that maximizes resources, departments, and faculty at the applicant institution to address the target population. Applicants are encouraged to propose collaborations with affiliated and/or local institutions, as appropriate. Applicants are also encouraged to partner with existing NIH-funded or other federally-funded resources and programs and leverage training activities from both federal and private-sector partners including, but not limited to, the following:

Funding Type
Internal Deadline
External Deadline
05/25/2024

NIH PAR-23-306: 2024 Biomedical Research Facilities (C06 Clinical Trial Not Allowed)

Institutionally Coordinated // Limit: 1 //  Contact RDS for more information

 

This Notice of Funding Opportunity (NOFO) invites applications from eligible academic and research institutions to apply for funding to modernize existing or construct new biomedical research facilities. Applications will be accepted from public and private nonprofit institutions of higher education as well as from non-profit research organizations. Applications from both research-intensive institutions and Institutions of Emerging Excellence (IEE) in biomedical research, both highly resourced and low-resourced institutions, from all geographic regions in the nation are strongly encouraged.

NIH recognizes the importance of all institutions of higher learning in contributing to the nation’s research capacity. The goal of this NOFO is to modernize biomedical research infrastructure to strengthen biomedical research programs. Each project is expected to provide long-term improvements to the institutional research infrastructure. Intended projects are the construction or modernization of core facilities and the development of other shared research infrastructure serving an institution-wide research community with broad impact on biomedical research.

Institutions with C06 awards funded under the Biomedical Research Facility Program (NOFOs PAR-21-139PAR-22-088 or PAR-23-045) are not eligible to apply to this NOFO, provided the awards are active on the receipt date for this NOFO. Thus, only one C06 Biomedical Research Facility active award per institution would be allowed at any given time.

 

Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum award budget from Federal funds is $8,000,000 direct cost. Applications with a budget less than $3,000,000 direct cost will not be considered. Since the scope of different projects will vary, it is anticipated that the size of the awards will vary.

Internal Deadline
External Deadline
01/25/2024

NINDS RFA-NS-23-030: 2023 Clinical Trial Methods in Clinical Neurological Disorders Course (R25 Clinical Trial Not Allowed)

No applicants // Limit: 1 // Tickets Available: 1 

Only one application per institution is allowed.

The purpose of the “Clinical Trial Methods in Neurological Disorders Course" Notice of Funding Opportunity (NOFO) is to support educational activities in the mission areas of NINDS. The overarching goal of this R25 is to attract investigators who are new to or with limited exposure to clinical research, promote training of this workforce with the long-term goal of increasing the reliability and effectiveness of clinical trials by 1) introducing the principles of good clinical practice to investigators in any clinical neuroscience subspecialty, thereby providing a foundation for scientifically rigorous and ethical performance of patient oriented clinical research 2) exposing early career clinical scientists to the challenges and potential solutions to overcome these challenges in clinical research and, 3) increasing the number and expertise of knowledgeable clinical research investigators in the workforce to enhance the pipeline of scientifically sound, well-designed clinical trials. Long term, the development of well-trained, experienced clinical researchers with expertise will foster better clinical trials design and thereby hasten the introduction of improved regimens for therapy and prevention of neurological disorders into everyday medical practice and patient care.

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on:

Courses for Skills Development: The goal of this activity is to support a clinical trial methodology course to train a group of talented, dedicated clinical neuroscience researchers to enable them to obtain external funding in the future. Key components of the course include a program of didactic lectures, individual or group projects, discussion sessions, and mentoring sessions.  The award will provide support for expenses for the implementation of the course in each year, including travel for all non-government course participants (faculty, advisors, and scholars) and all necessary materials and facilities, including meeting space, computer access, virtual meeting platform and course materials.

Research Experiences: An emphasis on early phase (i.e., phase I /II or pilot) trials within the mission areas of NINDS is essential, including pediatrics and rare diseases to address the full spectrum of neurological disorders. Developing trial designs for early phase trials are especially challenging yet critical to inform future scientific steps.  A major component of the educational course is expected to be small group protocol development sessions and individual one-on-one mentoring sessions with faculty, as well as outreach/engagement in the community to learn crucial aspects of trial development and potential recruitment. At the conclusion of the course, participant scholars should have developed a sound clinically relevant and feasible clinical trial protocol.

This NOFO aims to provide support for research education projects focused on clinical trial methodology in neurological disorders that are novel, innovative and designed to accomplish a specific goal based on a well-conceived evaluation plan. Applications will be expected to include a detailed plan to evaluate the effectiveness of the activities proposed and to include a plan for disseminating results of this program.

Research education programs may complement ongoing research training and education occurring at the applicant institution, but the proposed educational experiences must be distinct from those training and education programs currently receiving Federal support. R25 programs may augment institutional research training programs (e.g., T32, T90) but cannot be used to replace or circumvent Ruth L. Kirschstein National Research Service Award (NRSA) programs.

Funding Type
Internal Deadline
External Deadline
10/20/2023

NIH RFA-DK-23-001: 2023 Consortium for Gut-Brain Communication in Parkinsons Disease (U24 Clinical Trial not allowed)

No applicants // Limit: 1 // Tickets Available: 1 

 

Only one application per institution is allowed.

The purpose of this Notice of Funding Opportunity (NOFO) is to establish a Coordinating and Data Management Center (CDMC) that will coordinate and manage the activities of the Gastroenterology Neurology Research Centers (GNRCs), as described in the companion NOFO, RFA-DK-22-036, as part of the Gut Brain Parkinson's Disease Consortium (GBPDC). The responsibilities of the CDMC include, but are not limited to: (1) development of study protocols and coordination of enrollment of subjects into the study; (2) management of consortium-wide meetings and conferences, and cross-consortium collaborative activities; (3) provision of statistical and computational analysis support; and (4) establishing a central data hub for data capture, curation and management, and protocol development and registration. The CDMC will manage GBPDC-wide reporting and data and specimen sharing requirements, to include coordination of distribution of blood, biopsies, and other biological samples to the GNRCs. The CDMC will also manage the operations of the GBPDC Steering Committee and other operational committees and provide the infrastructure for the efficient design and conduct of multicenter studies and establish a repository of participant samples that may be used for ancillary studies of etiology and pathogenesis. NIDDK encourages applications from institutions that foster a diverse research environment, (for more information, see, e.g., NOT-OD-20-031), and encourages Research on Sex/Gender Differences, Sexual and Gender Minority-Related Research and Race/Ethnic Diversity (see NOT-DK-22-003). 

Funding Type
Internal Deadline
External Deadline
11/15/2023

NEI PAR-23-175: 2023 Center Core Grant for Vision Research (P30 Clinical Trial Not Allowed)

No applicants // Limit: 1 // Tickets Available: 1 

Only one application per institution is allowed.

The NEI Center Core Grant combines three or more Resource and/or Service Cores for a group of R01 investigators to enhance their research, consolidate resources, avoid duplication of efforts, and/or contribute to cost effectiveness by providing a service with lower costs or higher quality than could be attempted for independent projects by several individual Program Directors/Principal Investigators (PD(s)/PI(s)). Shared resources and facilities that are accessible to a group of independently funded investigators lead to greater productivity for the separate projects and can provide instrumentation and facilities that are too costly to be maintained by an individual investigator. The design and purpose of each Center Core may vary in how it serves its users. This program is designed to enhance an institution's environment and capability to conduct vision research and to facilitate collaborative studies of the visual system and its disorders and promote new research within the NEI mission and Strategic Plan. 

Funding Type
Internal Deadline
External Deadline
09/30/2023

NIH PAR-23-248: 2023 Institutional Network Award for Promoting Kidney, Urologic, and Hematologic Research Training (U2C - Clinical Trial Not Allowed)

No applicants // Limit: 1 // Tickets Available: 1 

 

Only one application per institution is allowed.

 

The purpose of this notice of funding opportunity is to invite Institutional Network Awards (U2C-TL1) to cultivate a highly integrated cohort of trainees and early career investigators and to develop career development resources to accelerate kidney, urologic, and hematologic research. To maximize integration and promote a true trainee community, Institutions are invited to submit a single, unified U2C-TL1 application to engage, recruit, prepare, and sustain the next generation of scientists able to contribute to advancing research in kidney, urology, and hematology. Applications representing multiple institutions within a single metropolitan area are strongly encouraged (see Section III.3). Successful awardees are expected to relinquish all active T32s supported by the NIDDK, Division of Kidney, Urologic, and Hematologic Diseases (KUH) at the time of the U2C-TL1 award. 

Funding Type
Internal Deadline
External Deadline
11/15/2023

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