The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612)
Submit Notice of Intent // Limit: 1 Phase I or Phase II Application per Focus Area
DOE plans to hold an informational webinar about this RFA on Thursday, March 26, 2026 at 3 PM Eastern. Registration information is linked here.
Limiting Language
Applicant institutions are limited to no more than one application as the lead institution per focus area for Phase I and Phase II applications combined. Phase II applications must list a primary focus area but will have the option to list secondary focus areas. The primary focus area will be used for determining limitations on institutional submissions.
There is no limitation to the number of applications for which the institution is not the lead in a multi-institution team using collaborative applications.
The PI on an application may also be listed as a senior or key personnel on an unlimited number of separate submissions but can be the lead PI on only one application. However, the PI on an awarded Phase I award may submit a Phase II proposal as part of the FY27 go/no-go decision process.
The full RFA is linked here.
Executive Summary
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.
DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
Additional applications for Phase I and Phase II may be submitted after the corresponding deadline listed on the cover of this RFA, however, DOE reserves the right to decline such applications without review.