NIAID is issuing this Notice of Special Interest (NOSI) to highlight the need for research on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19) in select scientific areas using the following funding mechanisms:
- PA-20-200 - NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
- PA-19-272 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
- PA-19-270 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
In order to rapidly improve our understanding and available control measures for SARS-CoV-2 and COVID-19, NIAID is encouraging the submission of applications to address the following research areas of interest:
- Studies to understand critical aspects of viral infection, replication, pathogenesis, and transmission;
- Studies on the evolution and emergence of SARS-CoV-2 viruses including the identification of factors that affect viral host-range and virulence;
- Development of sensitive, specific, and rapid clinical diagnostic tests for SARS-CoV-2;
- Development of SARS-COV-2 therapeutic candidates, especially broad-spectrum therapeutics against multiple coronavirus strains;
- Identification and evaluation of the innate, cellular and humoral immune responses to SARS-CoV-2 infection, including, but not limited to: cross-reactive antibodies from individuals exposed to SARS-CoV-2 and other coronaviruses; viral epitopes critical for T cell activation or antibody binding and neutralization; immune-mediated pathology or host factors that might predispose to severe infection; and studies to examine duration of protection or the potential for reinfection; and
- Development of SARS-CoV-2 vaccine candidates, including approaches for pan-coronavirus protection, that include emerging antigen design strategies, novel platforms or delivery approaches, adjuvants, or assessing cross-neutralization potential of SARS-CoV vaccine candidates.
Sponsor or Type
Deadline
June 16, 2020